基于真实头模型的经颅直流电刺激参数优选研究  

Effects of parameters selection with transcranial direct current stimulation based on real head model

作　　者：王宏利 于洪丽[1,2] 王超[1,2] 徐桂芝[1,2] 郭磊[1,2] WANG Hongli;YU Hongli;WANG Chao;XU Guizhi;GUO Lei(State Key Laboratory of Reliability and Intelligence of Electrical Equipment,Hebei University of Technology,Tianjin 300130,P.R.China;Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health,Hebei University of Technology,Tianjin 300130,P.R.China)

机构地区：[1]河北工业大学省部共建电工装备可靠性与智能化国家重点实验室,天津300130 [2]河北工业大学天津市生物电工与智能健康重点实验室,天津300130

出　　处：《生物医学工程学杂志》2021年第4期638-646,共9页Journal of Biomedical Engineering

基　　金：国家自然科学基金(51877068,81871469)。

摘　　要：经颅直流电刺激(tDCS)是一种脑刺激干预技术,目前刺激参数的选取缺乏统一标准。本文构建了四层真实头模型,应用有限元仿真技术分析了大脑电场分布随电流强度、电极形状和面积以及电极间距等的变化,探讨了电刺激参数的优选方案。结果显示,随着电流强度增加,有效刺激区域呈减少趋势,聚焦性增强;四边形电极作用后的法向电流密度明显大于圆形电极的数值,这意味着四边形电极更有利于对神经元的刺激,同时有效刺激区域集中,聚焦性更强;随着电极面积增大,聚焦性减弱;随着电极间距的增大,聚焦性呈先增强后减弱的趋势,最佳电极间距为64.0~67.2 mm。本研究结果可为电刺激参数的选取提供一定的依据。Transcranial direct current stimulation(tDCS)is a brain stimulation intervention technique,which has the problem of different criteria for the selection of stimulation parameters.In this study,a four-layer real head model was constructed.Based on this model,the changes of the electric field distribution in the brain with the current intensity,electrode shape,electrode area and electrode spacing were analyzed by using finite element simulation technology,and then the optimal scheme of electrical stimulation parameters was discussed.The results showed that the effective stimulation region decreased and the focusing ability increased with the increase of current intensity.The normal current density of the quadrilateral electrode was obviously larger than that of the circular electrode,which indicated that the quadrilateral electrode was more conducive to current stimulation of neurons.Moreover,the effective stimulation region of the quadrilateral electrode was more concentrated and the focusing ability was stronger.The focusing ability decreased with the increase of electrode area.Specifically,the focusing tended to increase first and then decrease with the increase of electrode spacing and the optimal electrode spacing was 64.0–67.2 mm.These results could provide some basis for the selection of electrical stimulation parameters.

关 键 词：经颅直流电刺激 电流强度 电极形状和面积 电极间距 

分 类 号：R741[医药卫生—神经病学与精神病学] R318[医药卫生—临床医学]