巨细胞病毒性角膜内皮炎的研究进展  

The research progress of cytomegalovirus corneal endotheliitis

作　　者：张爽 洪晶[1] Zhang Shuang;Hong Jing(Department of Ophthalmology,the Third Hospital of Peking University,Beijing 100191,China)

机构地区：[1]北京大学第三医院眼科,100191

出　　处：《中华眼科杂志》2021年第8期624-629,共6页Chinese Journal of Ophthalmology

基　　金：国家自然科学基金(81970768)。

摘　　要：巨细胞病毒性角膜内皮炎是由巨细胞病毒感染引起的角膜内皮炎性反应性疾病,主要发生于免疫功能正常的中老年人,且在亚洲地区的发病率相对较高。其典型的临床表现为局限性的角膜水肿、硬币状或线状角膜后沉积物、轻度的前房反应,可伴有眼压升高或反复发作的前葡萄膜炎病史。目前此病的发病机制不清,既往研究提出其与病毒感染及免疫反应有关,因此现阶段的治疗方案为经验性的抗病毒治疗联合局部糖皮质激素治疗。尽早的明确诊断及持续的抗病毒治疗,对于控制疾病进展、保护角膜内皮功能具有重要意义。Cytomegalovirus(CMV)corneal endotheliitis is an inflammatory disease of corneal endothelium caused by CMV infection.It mainly occurs in middle-aged and elderly immunocompetent people and has a relatively high incidence in Asia.It is characterized by localized corneal edema,coin-shaped or linear keratic precipitates and mild anterior chamber reaction,possibly with raised intraocular pressure or a history of recurrent anterior uveitis.The pathogenesis of this disease is not yet clear.Previous studies suggested it was related to viral infection and immune response;Therefore,the current treatment is empirically using antiviral agents combined with topical corticosteroids.Making an accurate early diagnosis and continuous antiviral therapy are crucial in controlling disease progression and preserving corneal endothelial function.

关 键 词：巨细胞病毒 角膜内皮炎 临床表现 诊断 治疗 

分 类 号：R772.21[医药卫生—眼科]