认识肠衰竭在重症急性胰腺炎发病中的作用  

The role of intestinal failure in the pathogenesis of severe acute pancreatitis

作　　者：王鹏飞 李幼生[1] Wang Pengfei;Li Yousheng(Department of General Surgery,Shanghai Ninth People′s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院普通外科,上海200011

出　　处：《中华医学杂志》2021年第30期2353-2355,共3页National Medical Journal of China

摘　　要：重症急性胰腺炎可诱发全身和局部并发症,其中感染性胰腺坏死及脓毒症主导了第二个死亡高峰。而肠衰竭引起的肠源性感染被认为是胰腺或胰周坏死继发性感染的重要机制。因此,肠衰竭的防治是重症急性胰腺炎治疗的重要环节,对病程和预后有重要影响。应根据治疗中心的自身优势和患者的特点来选择个体化治疗方案。Severe acute pancreatitis can induce systemic and local complications,with infectious pancreatic necrosis and sepsis leading to the second death peak.Enterogenous infection caused by intestinal failure is considered to be an important mechanism of secondary infection of pancreatic or peripancreatic necrosis.Therefore,the prevention and treatment of intestinal failure is the key point in the treatment of severe acute pancreatitis and has an important influence on the course and prognosis of the disease.Individualized treatment should be selected according to the advantages of treatment centers and the characteristics of patients.

关 键 词：胰腺炎 急性坏死性 肠衰竭 肠源性感染 肠血管屏障 

分 类 号：R576[医药卫生—消化系统]