The interplay between hepatocyte nuclear factor 4α(HNF4α)and cholesterol sulfotransferase(SULT2B1b)in hepatic energy homeostasis  

作　　者：Yuhan Bi Youya Wang Wen Xie 

机构地区：[1]Center for Pharmacogenetics,Department of Pharmaceutical Sciences,University of Pittsburgh,Pittsburgh,PA,USA [2]Department of Pharmacology and Chemical Biology,University of Pittsburgh,Pittsburgh,PA,USA

出　　处：《Liver Research》2019年第3期143-149,共7页肝脏研究（英文）

基　　金：supported in part by the USA National Institutes of Health(NIH)grants DK099232,ES023438 and ES030429 to W.Xie.W.Xie was supported in part by the Joseph Koslow Endowed Professorship from the University of Pittsburgh School of Pharmacy.

摘　　要：The nuclear receptor hepatocyte nuclear factor 4alpha(HNF4α)plays a critical role in the regulation of metabolic homeostasis,including glucose homeostasis.Sulfotransferases(SULTs)catalyze the transfer of a sulfate group from 3-phosphoadenosine 5-phosphosulfate(PAPS)to an acceptor molecule.Sulfonation plays an essential role in regulating the chemical and functional homeostasis of endogenous and exogenous molecules.Among SULTs,the cholesterol sulfotransferase 2B1b(SULT2B1b)preferentially catalyzes the sulfoconjugation of cholesterol and oxysterols to form cholesterol sulfate and oxysterol sulfates.Hepatic gluconeogenesis represents a critical component of energy metabolism.Although there have been reviews on the regulation of glucose homeostasis by HNF4a,the interplay between HNF4a and SULT2B1b in hepatic glucose homeostasis remains scattered.In this review,we intend to provide an overview on how HNF4a functionally cross-talks with SULT2B1b to regulate hepatic glucose homeostasis and whether the HNF4a-SULT2B1b axis represents a novel therapeutic target for the management of metabolic liver disease and metabolic syndrome.

关 键 词：Nuclear receptor Hepatocyte nuclear factor 4alpha(HNF4a) Sulfotransferase(SULT) Cholesterol sulfotransferase 2B1b (SULT2B1b)Energy homeostasis 

分 类 号：R57[医药卫生—消化系统]