苄基苯基三氮唑查尔酮的合成  

Synthesis of Benzyl Phenyl Triazolyl Chalcone

作　　者：吴胜菲 刘磊[1] 李涛 张启越 贺立峰 张纯祎 吕振[1] Wu Shengfei;Liu Lei;Li Tao;Zhang Qiyue;He Lifeng;Zhang Chunyi;Lv Zhen(Qiqihar Medical University,Pharmacy,Qiqihar 161006,China)

机构地区：[1]齐齐哈尔医学院药学院,黑龙江齐齐哈尔161006

出　　处：《广东化工》2021年第11期27-28,共2页Guangdong Chemical Industry

基　　金：黑龙江省大学生创新创业计划训练项目(202011230025)。

摘　　要：以丙炔醇为原料,两步反应得到2-苄基-5-苯基-1,2,3-三氮唑查尔酮,再与邻羟基苯乙酮发生羟醛缩合反应,高效的得到新型苄基三氮唑查尔酮,并通过1H NMR,13C NMR对目标产物进行了表征。通过考察反应溶剂、反应时间以及醛酮投料比对产物收率的影响,确定了最优反应条件:以甲醇为反应溶剂,回流反应3 h,醛酮投料比为1∶1.2时,目标产物反应产率相对较高,目标产物产率为76%。Using propynol as raw material, 2-Benzyl-5-phenyl-1,2,3-triazolyl chalcone is obtained by two-step reaction, and then aldol condensation reaction occurs with o-hydroxyacetophenone to efficiently obtain new benzyl The target product was characterized by 1 H NMR and 13C NMR. By investigating the influence of reaction solvent, reaction time and aldehyde and ketone feeding ratio on the product yield, the optimal reaction conditions were determined: methanol was used as the reaction solvent, reflux reaction for 3 h, when the aldehyde and ketone feeding ratio was 1∶1.2, the target product reacted The yield is relatively high, and the target product yield is 76 %.

关 键 词：三氮唑 查尔酮 羟醛缩合 

分 类 号：O626.1[理学—有机化学]