三氟甲磺酸铜催化二取代烯酮与吡咯的傅克酰基化反应  

Cu(OTf)_(2)-Catalyzed Friedel-Crafts Acylation Reaction of Disubstituted Ketenes and Pyrroles

作　　者：王乾毅 信学雷[1] 卢崇道[1] Wang Qianyi;Xin Xuelei;Lu Chongdao(CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions,State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization,Xinjiang Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Urumqi,Xinjiang 830011,China;School of Chemistry and Chemical Engineering,University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院干旱区植物资源化学重点实验室新疆特有药用资源利用省部共建国家重点实验室培育基地中国科学院新疆理化技术研究所,新疆乌鲁木齐830011 [2]中国科学院大学化学化工学院,北京100049

出　　处：《化学世界》2021年第8期459-465,共7页Chemical World

基　　金：国家自然科学基金(No.U1403301)资助项目。

摘　　要：研究了二取代烯酮与吡咯在Lewis酸催化条件下发生的傅克酰基化反应。发现在三氟甲磺酸铜(Ⅱ)为催化剂的条件下,二取代的烯酮与N-H吡咯反应可以得到良好收率的2-位酰化的吡咯衍生物,该研究为合成含有α,α-二取代酰基的2-位酰化吡咯衍生物提供了可行的方法。Friedel-Crafts acylation reaction between disubstituted ketenes and pyrroles in the presence of catalytic amount of Lewis acids was investigated.Using Cu(OTf)_(2)as catalyst,the reactions of disubstituted ketenes and free(N-H)pyrroles afforded a series of 2-acylated pyrrole derivatives in good yields,which are reported for the first time.This report provided a new protocol for the synthesis of 2-acyl pyrroles bearingα,α-disubstituted acyl groups.

关 键 词：吡咯 烯酮 路易斯酸催化 傅克酰基化 

分 类 号：O621.3[理学—有机化学]