细菌对抗生素与重金属的联合抗性机制研究进展  

Research advances on the co-contaminated resistance mechanism of antibiotics and heavy metals in bacteria

作　　者：戎玲玲 王复标 吴礼贵 冯关萍 肖小雨[1] 邹小明[1] RONG Lingling;WANG Fubiao;WU Ligui;FENG Guanping;XIAO Xiaoyu;ZOU Xiaoming(College of Life Sciences,Jinggangshan University,Ji’an Jiangxi 343009)

机构地区：[1]井冈山大学生命科学学院,江西吉安343009

出　　处：《环境污染与防治》2021年第8期1062-1068,1076,共8页Environmental Pollution & Control

基　　金：江西省教育厅科技计划青年项目(No.GJJ190569);井冈山大学博士科研启动项目(No.JZB1901);江西省自然科学基金资助项目(No.20181BAB203023、No.20192BAB214014);江西省博士后择优资助项目(No.2019KY48);邹小明杰出青年人才资助计划项目(No.20192BCBL23014)。

摘　　要：抗生素抗性基因(ARGs)和重金属抗性基因(HRGs)已被普遍视为新型环境污染物,二者之间存在联合抗性机制。因此,抗生素和重金属联合污染下细菌的抗性研究受到了广泛关注。总结了细菌中ARGs和HRGs的来源,综述了协同抗性、交叉抗性、协同调控抗性和生物被膜抗性4种联合抗性机制,并对今后的研究方向进行了展望,对新型抗菌药物的开发、解释或推测联合抗性发生的原因具有一定的指导意义。Antibiotics resistance genes(ARGs)and heavy metals resistance genes(HRGs)are considered as emergent environmental pollutants commonly.Environmental bacteria are generally exposed to combinations of these pollutants.Therefore,the study of bacterial resistance under the co-contamination of antibiotics and heavy metals has attracted extensive attention.The origin of ARGs and HRGs in bacteria was summarized.4 co-contaminated resistance mechanisms,namely co-resistance mechanism,cross-resistance mechanism,co-regulation resistance mechanism and biofilm resistance mechanism were reviewed.The future research directions were prospected.It had important significance for the development of new antibacterial agent and explanation for co-contaminated resistance mechanisms.

关 键 词：协同抗性 交叉抗性 协同调控抗性 生物被膜抗性 

分 类 号：X172[环境科学与工程—环境科学]