MiRNA-145在肿瘤表达中的生物学意义研究进展  

Research progress in biological significance of miRNA-145 expression in tumor

作　　者：王雪振(综述) 夏雷(审校)[2] WANG Xuezhen;XIA Lei(College of Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250355,China;Faculty of Pathology,Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250355,China)

机构地区：[1]山东中医药大学中医学院,济南250355 [2]山东中医药大学病理学系,济南250355

出　　处：《重庆医学》2021年第16期2826-2830,共5页Chongqing medicine

基　　金：国家自然科学基金青年科学基金项目(81703839)。

摘　　要：微RNA-145(miRNA-145)的表达在多种肿瘤的生长抑制、转移、侵袭及化疗敏感度等方面起着重要的调控作用。肿瘤组织细胞高表达miRNA-145可抑制原癌基因激活,而下调miRNA-145表达,可降低抑制原癌基因表达的能力,癌细胞生长、增殖甚至转移。本文就miRNA-145在卵巢癌、胃癌、肺癌、乳腺癌、前列腺癌等肿瘤的研究进展作一综述,为miRNA-145在肿瘤早期诊断、预后判断、病情评估,以及作为肿瘤潜在治疗靶点的可能机制提供依据。The expression of microRNA-145(miRNA-145)plays an important regulatory role in the aspects of growth inhibition,metastasis,invasion and chemotherapy sensitivity of multiple tumors.High expression of miRNA-145 in tumor tissue cells can inhibit the proto-oncogene activation,while down-regulating the miRNA-145 expression can reduce the ability for inhibiting proto-oncogene expression,growth,proliferation,even metastasis of cancer cells.This article reviewed the research progress of miRNA-145 in ovarian cancer,gastric cancer,lung cancer,breast cancer,prostate cancer and other tumors,in order to provide references for miRNA-145 in the early diagnosis of tumors,prognosis judgment,disease evaluation,and possible mechanisms as a potential therapeutic target of tumor.

关 键 词：微RNA-145 恶性肿瘤 早期诊断 预后判断 病情评估 靶点 

分 类 号：R730.43[医药卫生—肿瘤]