Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases  

作　　者：Eric K.Kwong Huiping Zhou 

机构地区：[1]Department of Microbiology and Immunology,Virginia Commonwealth University,Richmond,VA,USA [2]McGuire VA Medical Center,Richmond,VA,USA

出　　处：《Liver Research》2019年第1期19-24,共6页肝脏研究（英文）

基　　金：This work was supported by the USA National Institutes of Health(NIH)grants R01 DK104893 and R01DK-057543;VA Merit Award I01BX004033 and 1I01BX001390;Research Career Scientist Award(IK6BX004477)from the Department of Veterans Affairs.

摘　　要：The liver is the central organ involved in lipid metabolism and the gastrointestinal(GI)tract is responsible for nutrient absorption and partitioning.Obesity,dyslipidemia and metabolic disorders are of increasing public health concern worldwide,and novel therapeutics that target both the liver and the GI tract(gut-liver axis)are much needed.In addition to aiding fat digestion,bile acids act as important signaling molecules that regulate lipid,glucose and energy metabolism via activating nuclear receptor,G protein-coupled receptors(GPCRs),Takeda G protein receptor 5(TGR5)and sphingosine-1-phosphate receptor 2(S1PR2).Sphingosine-1-phosphate(S1P)is synthesized by two sphingosine kinase isoforms and is a potent signaling molecule that plays a critical role in various diseases such as fatty liver,in-flammatory bowel disease(IBD)and colorectal cancer.In this review,we will focus on recent findings related to the role of S1P-mediated signaling pathways in the gut-liver axis.

关 键 词：Sphingosine-1-phosphate(S1P) Sphingosine kinase 2(SphK2) Sphingosine-1-phosphate receptor 2 (S1PR2) Gut-liver axis Liver diseases 

分 类 号：R57[医药卫生—消化系统]