Nuclear receptors and non-alcoholic fatty liver disease:An update  

作　　者：Xiao Yang Frank J.Gonzalez Min Huang Huichang Bi 

机构地区：[1]Guangdong Provincial Key Laboratory of New Drug Design and Evaluation,School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,China [2]Laboratory of Metabolism,Center for Cancer Research,National Cancer Institute,NIH,Bethesda,MD,USA

出　　处：《Liver Research》2020年第2期88-93,共6页肝脏研究（英文）

基　　金：The work was supported by the Natural Science Foundation of China(81973392,81320108027);the National Key Research and Development Program of China(2017YFE0109900);the Natural Science Foundation of Guangdong Province(2017A030310330,2017A030311018);China Postdoctoral Science Foundation(2019TQ0398);the Fundamental Research Funds for the Central Universities(19ykyjs34).

摘　　要：Non-alcoholic fatty liver disease(NAFLD)has become the leading cause of chronic liver disease in adults and children worldwide.The symptoms of NAFLD range from simple steatosis and non-alcoholic stea-tohepatitis(NASH)to hepatic fibrosis or cirrhosis,even ultimately develops to hepatocellular carcinoma.Nuclear receptors(NRs)are a superfamily of ligand-activated transcription factors,most of which are ligand-activated that control cellular homeostasis in the liver and other tissues.A growing number of studies demonstrated the important role of NRs in NAFLD.In this review,the current findings on the role of NRs in NAFLD are summarized and future perspectives to target NRs for NAFLD are discussed.

关 键 词：Nuclear receptors(NRs) Non-alcoholic fatty liver disease(NAFLD) Pregnane X receptor(PXR) Constitutive androstane receptor(CAR) Farnesoid X receptor(FXR) Peroxisome proliferator activated receptor (PPAR) Liver X receptor(LXR) 

分 类 号：R575.5[医药卫生—消化系统]