Palladium-catalyzed asymmetric carbamoyl-carbonylation of alkenes  

作　　者：Ziwen Feng Qiuyu Li Long Chen Hequan Yao Aijun Lin 

机构地区：[1]State Key Laboratory of Natural Medicines(SKLNM)and Department of Medicinal Chemistry,School of Pharmacy,China Pharmaceutical University,Nanjing,210009,China

出　　处：《Science China Chemistry》2021年第8期1367-1371,共5页中国科学（化学英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(22071267);the Open Project of State Key Laboratory of Natural Medicines(SKLNMZZ202023);the Innovation Team of“the Double-First Class”Disciplines(CPU2018GY35).

摘　　要：An unprecedented palladium-catalyzed asymmetric carbamoyl-carbonylation of tethered alkenes with CO and alcohols has been developed.This reaction provided an efficient route to access oxindoles andγ-lactams bearingβ-carbonyl substituted quaternary carbons in good yields with excellent chemo-,regio-and enantioselectivity.Gram-scale synthetic capability and facile transformations of the products to chiral spirooxindole and other functional molecules further illustrated the practicability of this reaction.

关 键 词：CARBONYLATION OXINDOLES γ-lactams asymmetric catalytic synthesis quaternary carbon stereocenters 

分 类 号：O621.251[理学—有机化学]