Fish sharing as a risk factor for Opisthorchis viverrini infection:evidence from two villages in north-eastern Thailand  

作　　者：Parichat Saenna Cameron Hurst Pierre Echaubard Bruce AWilcox Banchob Sripa 

机构地区：[1]WHO Collaborating Centre for Research and Control of Opisthorchiasis(Southeast Asian Liver Fluke Disease),Tropical Disease Research Laboratory,Department of Pathology,Faculty of Medicine,Khon Kaen University,123 Mittraparb Road,Khon Kaen 40002,Thailand [2]Biostatistics Center of Excellence,Faculty of Medicine,Chulalongkorn University,Bangkok 10330,Thailand [3]Global Health Asia,Integrative Research and Education Program,Faculty of Public Health,Mahidol University,Bangkok,Thailand [4]Department of Biology,Laurentian University,935 Ramsey Lake Road,Sudbury P3E2C6,ON,Canada [5]Present Address:Faculty of Education,Khon Kaen University,Khon Kaen,Thailand

出　　处：《Infectious Diseases of Poverty》2017年第1期564-572,共9页贫困所致传染病（英文）

基　　金：This work was partially supported by the Higher Education Research Promotion and National Research University Project of Thailand,Office of the Higher Education Commission,through the Health Cluster(SHeP-GMS);Khon Kaen University,Thailand;the Thailand Research Fund(RTA 5680006);the National Institute of Allergy and Infectious Diseases(NIAID),National Institute of Health(NIH);award number P50AI098639;The content is solely the opinion of the authors and does not necessarily represent the official views of NIAID,the NIH,or the funders.

摘　　要：Background:Foodborne trematodiasis(FBT)is a significant global health problem,with the liver flukes Opisthorchis viverrini,O.felineus,and Clonorchis sinensis contributing to half of the global burden of FBT.North-eastern Thailand where O.viverrini is endemic and un-cooked fish dishes remain an integral part of the food culture has the highest reported incidence of opisthorchiasis,including associated cholangiocarcinoma.Both food sharing and eating practices are potentially important factors in FTB,suggesting an important role for the social ecology of disease transmission in these rural communities.Methods:Two rural Thai-Lao villages that were part of a 12-village project in Northeastern Thailand were selected for detailed investigation of O.viverrini infection risk associated with sharing of raw fish dishes among households.The project included screening individuals for infection and cholangiocarcinoma,a household questionnaire,and offering treatment options for positive individuals.Social network mapping was used to construct raw fish dish-sharing networks and create a proxy variable capturing variability in the degree of food sharing(DFS),measured as the number of different households with which each household shared fish dishes.Measures of associations between DFS,O.viverrini infection,the frequency of raw fish consumption,and the number of raw fish dishes consumed were generated using binary logistic regression,proportional odds ordinal logistic regression,and Poisson regression.Results:The results showed that the probability that a household has members infected with O.viverrini increased by~7%(P<0.01)for each additional household included in its network.Moreover,the frequency and number of types of raw fish dishes consumed increased significantly as the DFS increased.Of the two villages,that with the highest infection prevalence(48%versus 34.6%)had significantly higher social connectivity overall(P<0.001).Conclusions:Our findings suggest that the social ecology of human settlements may be key to understand

关 键 词：Foodborne trematodes Opisthorchis viverrini Opisthorchiasis prevention and control Food sharing Raw fish dishes Social network analysis Thailand 

分 类 号：R73[医药卫生—肿瘤]