Schistosomiasis in immigrants,refugees and travellers in an Italian referral centre for tropical diseases  

作　　者：Valentina Marchese Anna Beltrame Andrea Angheben Geraldo Badona Monteiro Giovanni Giorli Francesca Perandin Dora Buonfrate Zeno Bisoffi 

机构地区：[1]Centre for Tropical Diseases,Sacro Cuore Don Calabria Hospital,Via Sempreboni 5,37024 Negrar,Italy [2]University Department of Infectious and Tropical Diseases&WHO Collaborating Centre for TB/HIV and TB elimination,University of Brescia,Piazzale Spedali Civili 1,25123 Brescia,Italy

出　　处：《Infectious Diseases of Poverty》2018年第1期531-540,共10页贫困所致传染病（英文）

摘　　要：Background:Schistosomiasis is one of the most important neglected tropical diseases.If unrecognised and untreated,the chronic infection can lead to irreversible complications.Methods:Retrospective observational study aimed at describing clinical history,laboratory findings and imaging presentation of imported schistosomiasis diagnosed at the Centre for Tropical Diseases,Sacro Cuore Don Calabria Hospital of Negrar,Verona,Italy from 2010 to 2014.The aim of our study was to assess differences in demographic characteristics,clinical presentation,laboratory data and ultrasound findings between immigrants/visiting friends and relatives(VFR)from endemic countries(endemic group)and expatriates/travellers(non-endemic group).Results:A total of 272 patients were retrieved:234 in the endemic and 38 in the non-endemic group.Most of the patients acquired schistosomiasis in Africa(97.4%).Symptoms were reported by 52.9%of the patients;abdominal pain(36%),macroscopic hematuria(11.3%),and genito-urinary symptoms(7.4%)being the most frequently reported.Increased IgE and blood eosinophilia were observed in 169(63.8%)and 130(47.8%)patients,respectively.The proportion of positive serology was 250/272(91.9%).The Circulating Cathodic Antigen CCA for Schistosoma mansoni was positive in 14/61 individuals(23%).At microscopy,infected subjects were 103/272(37.9%).The species of Schistosoma found were S.haematobium(47.6%),S.mansoni(46.6%)or both(5.8%).Schistosomiasis was classified as confirmed in 103(37.9%),probable in 165(60.6%)and suspected in 4(1.5%)cases using clinical presentation,laboratory data and ultrasound findings.The infection was further classified based on organ involvement:intestinal(17.9%),hepatosplenic(5.1%),urogenital(48.9%),and indeterminate(43.8%).The comparative analysis of endemic and non-endemic patients highlighted differences in sex and age.Endemic patients had more frequent ova identification(41.9%vs.13.2%,P<0.001)and increased IgE(70%vs.26.3%,P<0.001)when compared with non-endemic.Multivariate analyses showed that

关 键 词：SCHISTOSOMIASIS Neglected tropical diseases IMMIGRANTS Refugees TRAVELLERS Europe Italy 

分 类 号：R73[医药卫生—肿瘤]