Toxocariasis:a silent threat with a progressive public health impact  

作　　者：Jia Chen Quan Liu Guo-Hua Liu Wen-Bin Zheng Sung-Jong Hong Hiromu Sugiyama Xing-Quan Zhu Hany M.Elsheikha 

机构地区：[1]State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,1 Xujiaping,Yanchangbu,Lanzhou,Gansu Province 730046,People’s Republic of China [2]Ningbo University School of Medicine,Ningbo,Zhejiang Province,People’s Republic of China [3]Military Veterinary Institute,Academy of Military Medical Sciences,Key Laboratory of Jilin Province for Zoonosis Prevention and Control,Changchun,Jilin Province,People’s Republic of China [4]College of Veterinary Medicine,Hunan Agricultural University,Changsha,Hunan Province,People’s Republic of China [5]Department of Medical Environmental Biology,Chung-Ang University College of Medicine,Seoul,South Korea [6]Department of Parasitology,National Institute of Infectious Diseases,Tokyo,Japan [7]Faculty of Medicine and Health Sciences,School of Veterinary Medicine and Science,University of Nottingham,Loughborough,UK

出　　处：《Infectious Diseases of Poverty》2018年第1期570-582,共13页贫困所致传染病（英文）

基　　金：This study was financially supported by the Elite Program of Chinese Academy of Agricultural Sciences,the International Science&Technology Cooperation Program of China(grant No.2013DFA31840);the Agricultural Science and Technology Innovation Program(ASTIP)(Grant No.CAAS-ASTIP-2016-LVRI-03).

摘　　要：Background:Toxocariasis is a neglected parasitic zoonosis that afflicts millions of the pediatric and adolescent populations worldwide,especially in impoverished communities.This disease is caused by infection with the larvae of Toxocara canis and T.cati,the most ubiquitous intestinal nematode parasite in dogs and cats,respectively.In this article,recent advances in the epidemiology,clinical presentation,diagnosis and pharmacotherapies that have been used in the treatment of toxocariasis are reviewed.Main text:Over the past two decades,we have come far in our understanding of the biology and epidemiology of toxocariasis.However,lack of laboratory infrastructure in some countries,lack of uniform case definitions and limited surveillance infrastructure are some of the challenges that hindered the estimation of global disease burden.Toxocariasis encompasses four clinical forms:visceral,ocular,covert and neural.Incorrect or misdiagnosis of any of these disabling conditions can result in severe health consequences and considerable medical care spending.Fortunately,multiple diagnostic modalities are available,which if effectively used together with the administration of appropriate pharmacologic therapies,can minimize any unnecessary patient morbidity.Conclusions:Although progress has been made in the management of toxocariasis patients,there remains much work to be done.Implementation of new technologies and better understanding of the pathogenesis of toxocariasis can identify new diagnostic biomarkers,which may help in increasing diagnostic accuracy.Also,further clinical research breakthroughs are needed to develop better ways to effectively control and prevent this serious disease.

关 键 词：Toxocara canis TOXOCARIASIS ZOONOSIS Larva migrans EPIDEMIOLOGY Diagnosis Control 

分 类 号：R57[医药卫生—消化系统]