Outbreak of Crimean-Congo haemorrhagic fever with atypical clinical presentation in the Karak District of Khyber Pakhtunkhwa,Pakistan  

作　　者：Khalid Rehman Muhammad Asif Khan Bettani Luzia Veletzky Shaheen Afridi Michael Ramharter 

机构地区：[1]Department of Medicine I,Division of Infectious Diseases and Tropical Medicine,Medical University of Vienna,Währinger Gürtel 18-20,1090 Vienna,Austria [2]Department of health Khyber Pakhtunkhwa,Gate#5 opposite Pearl Continental hotel Main GT road Peshawar,Peshawar 25000,Pakistan [3]Institute of Tropical Medicine,University of Tübingen,WilhelmstraBe 27,72074 Tubingen,Germany [4]Department of Tropical Medicine,Bernhard Nocht Institute for Tropical Medicine&I Department of Medicine,University Medical Center Hamburg-Eppendorf,Bernhard-Nocht-Straße 74,20359 Hamburg,Germany

出　　处：《Infectious Diseases of Poverty》2018年第1期1211-1216,共6页贫困所致传染病（英文）

摘　　要：Background:Crimean-Congo haemorrhagic fever(CCHF)is a potentially fatal disease endemic in Pakistan.The causative virus is transmitted by the bite of Hyalomma ticks or by contact with infected blood or tissue.First cases of the disease were reported in Pakistan in 1976 but regular outbreaks have been observed since the year 2000.A huge agricultural base with more than 175 million livestock,the concomitant presence of Hyalomma ticks and a lack of precautionary measures to prevent transmission lead to a considerable risk for exposed populations to contract CCHF in Pakistan.At the same time,secondary cases contracted by nosocomial transmission are reported from hospitals.Case presentation:Here we present an outbreak of CCHF with four of six patients succumbing to the disease before the suspicion for CCHF was raised.Importantly,the main clinical features of these cases were gastrointestinal symptoms without any clinical signs of bleeding.Only the last two patients in this outbreak presented with typical signs of bleeding disorder and were then confirmed being infected by CCHF.Confirmation of diagnosis was done at the National Institute of Health by real-time RT-PCR.Conclusions:This case series highlights the importance of early clinical suspicion for CCHF in exposed individuals and the need for improved precautionary measures against the spread of CCHF within the Pakistani population and hospitals.

关 键 词：Crimean Congo haemorrhagic fever GI symptoms OUTBREAK Contact tracing 

分 类 号：R73[医药卫生—肿瘤]