阿尔茨海默病患者硫胺素缺乏相关的精神行为症状病例报告  

A Case Report of psychotic symptoms as clinical presentation of thiamine deficiency in an Alzheimer's disease patient

作　　者：周益萍 魏文石 ZHOU Yi-ping;WEI Wen-shi(Huadong Hospital Affiliated to Fudan University,Department of Neurology,Center of Cogntive Disorder,Shanghai 200040,China)

机构地区：[1]复旦大学附属华东医院神经内科·华东医院认知障碍中心,上海200040

出　　处：《阿尔茨海默病及相关病杂志》2021年第2期124-126,共3页Chinese Journal of Alzheimer's Disease and Related Disorders

摘　　要：非酒精性硫胺素缺乏的病例发病率较低,临床上易被忽视,延误治疗容易导致韦尼克脑病,柯萨可夫综合征等。而阿尔茨海默病患者的精神行为症状(BPSD)与硫胺素缺乏之间关联的报道极少。本次介绍一患有阿尔茨海默病的老年男性因精神行为症状的急剧恶化而来我院就诊。有进食减少病史,在给予较大剂量硫胺素补充后症状得到明显改善。同时建议在怀疑硫胺素缺乏的任何情况下都可开始硫胺素的补充治疗,其所带来的潜在收益远超不治疗的风险。The incidence of thiamine deficiency(TD)induced by non-alcoholic diseases is very low,which is often neglected clinically,resulting in Wernicke encephalopathy(WE)or Korsakoff syndrome caused by the delay in the treatment of this disease.Few cases have been reported the association between the exacerbation of the psychiatric symptoms of Alzheimer's disease(AD)patient and thiamine deficiency.An old man with AD visited our clinic because of acute deterioration in psychological symptoms of dementia(BPSD),with a decrease in food intake lasting more than 1 month,symptoms were improved significantly after thiamine administration.It is recommended that the treatment with TD can be started in any situation where thiamine deficiency is suspected.The potential benefits brought by it far outweigh the risks of no treatment.Meanwhile,it is recommended that therapeutic administration of thiamine be commenced in any case where thiamine deficiency is suspected,the potential benefits to a patient with possible thiamine deficiency far outweigh the risks of not treating.

关 键 词：硫胺素缺乏 精神行为症状 韦尼克脑病 病例报告 

分 类 号：R741[医药卫生—神经病学与精神病学]