益肺宣肺降浊中药颗粒对脑梗死患者Lp-PLA2、Hcy、MMP-9及颈动脉斑块的影响  

Effect of Yifei Xuanfei Jiangzhuo Granules of Chinese Medicine on Lp-PLA2,Hcy,MMP-9,and Carotid Plaque of Patients with Cerebral Infarction

作　　者：黄彬森[1] 邢俊娥[2] 吴鹏[2] HUANG Binsen;XING Jun'e;WU Peng

机构地区：[1]平舆县人民医院,河南平舆463400 [2]广西中医药大学第一附属医院,广西南宁530001

出　　处：《新中医》2021年第15期68-71,共4页New Chinese Medicine

摘　　要：目的:探讨联合益肺宣肺降浊中药颗粒对脑梗死患者血浆脂蛋白相关磷脂酶A2(Lp-PLA2)、同型半胱氨酸(Hcy)、基质金属蛋白酶-9(MMP-9)及颈动脉斑块的影响。方法:收集脑梗死发生1272 h内选择河南省平舆县人民医院治疗的患者66例,按随机数字表法分为常规治疗组33例和中药组33例,常规治疗组按脑梗死急性期给予常规治疗,中药组在常规治疗组的基础之上加用益肺宣肺降浊中药颗粒;2组患者治疗前、治疗1、6个月后检测血浆Lp-PLA2、Hcy、MMP-9以及治疗6个月后患者颈动脉内中膜厚度(IMT)、斑块的面积以及斑块数量的变化,并比较2组治疗前后美国国立卫生院神经功能缺损评分(NIHSS)评分变化。结果:治疗前,2组血浆MMP-9比较,差异无统计学意义(P>0.05);治疗1、6个月后,2组血浆MMP-9均降低(P<0.05),且与常规治疗组比较,中药组降低更为明显(P<0.05)。治疗前,2组血浆Hcy比较,差异无统计学意义(P>0.05);治疗后,2组血浆Hcy均有不同程度降低(P<0.05),且与常规治疗组比较,中药组降低更为明显(P<0.05)。治疗前,2组血浆Lp-PLA2比较,差异无统计学意义(P>0.05);治疗后,2组血浆Lp-PLA2均降低(P<0.05),与常规治疗组比较,中药组降低程度高于常规治疗组,差异有统计学意义(P<0.05)。治疗前,2组颈动脉彩超提示,IMT值、斑块数量及斑块的面积比较,差异无统计学意义(P>0.05);治疗6个月后复查颈动脉彩超提示,各组IMT值、斑块数量及斑块的面积较治疗前下降,差异有统计学意义(P<0.05),且与常规治疗组比较,中药组IMT值、斑块数量及斑块的面积下降程度较明显(P<0.05)。治疗前,2组NIHSS评分比较,差异无统计学意义(P>0.05);治疗1个月后、6个月后,2组NIHSS评分均呈下降趋势,差异有统计学意义(P<0.05),且与常规治疗组比较,中药组NIHSS评分改善优于常规治疗组(P<0.05)。结论:联合益肺宣肺降浊中药颗粒能显著降低脑梗死患者Lp-PLA2、HObjective:To discuss the effect of Yifei Xuanfei Jiangzhuo granules of Chinese medicine on lipoproteinassociated phospholipase A2(LP-PLA2),homocysteine(Hcy),matrix metalloproteinase-9(MMP-9)in plasma,and carotid plaque of patients with cerebral infarction.Methods:A total of 66 cases of patients who were treated at Pingyu People’s Hospital in Henan Province within 12-72 hours after the onset of cerebral infarction were selected,and divided into the routine treatment group and the Chinese medicine group according to the random number table method,33 cases in each group.The routine treatment group was given routine treatment of cerebral infarction at acute stage,and the Chinese medicine group was additionally given Yifei Xuanfei Jiangzhuo granules of Chinese medicine based on the treatment of the control group.Before treatment as well as after one-month and six-month treatment,changes in levels of Lp-PLA2,Hcy,and MMP-9 is plasma were detected in the two groups.After six-month treatment,changes in carotid intima-media thickness(IMT),the numbers and size of plaque were detected in the two groups.Before and after treatment,changes in the score of National Institutes of Health Stroke Scale(NIHSS)were compared between the two groups.Results:Before treatment,there was no significant difference being found in the comparison of the level of plasma MMP-9 between the two groups(P>0.05).After one month and six-month treatment,levels of plasma MMP-9 in the two groups were decreased(P>0.05),and the decrease in the Chinese medicine group was more significant than that in the routine treatment group(P<0.05).Before treatment,there was no significant difference being found in the comparison of the level of plasma Hcy between the two groups(P>0.05).After treatment,levels of plasma Hcy in the two groups were decreased at different degrees(P<0.05),and the decrease in the Chinese medicine group was more significant than that in the routine treatment group(P<0.05).Before treatment,there was no significant difference being found in the

关 键 词：脑梗死 益肺宣肺降浊中药颗粒 血浆脂蛋白相关磷脂酶A2 同型半胱氨酸 基质金属蛋白酶 颈动脉斑块 

分 类 号：R743.3[医药卫生—神经病学与精神病学]