环状核糖核酸调节肾透明细胞癌生物学行为的研究进展  

Research Progress of CircRNAs Regulating Biological Behavior of Clear Cell Renal Cell Carcinoma

作　　者：张慧杰 刘利婷 崔宏伟[1] 于蕾 岳根全[3] ZHANG Huijie;LIU Liting;CUI Hongwei;YU Lei;YUE Genquan(Clinical Research Center,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Department of Pharmacy,Traditional Chinese Medicine Hospital of Inner Mongolia Autonomous Region,Hohhot 010020,China;Department of Urology,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学附属医院临床研究中心,呼和浩特010050 [2]内蒙古中医医院药剂科,呼和浩特010020 [3]内蒙古医科大学附属医院泌尿外科,呼和浩特010050

出　　处：《肿瘤防治研究》2021年第8期814-819,共6页Cancer Research on Prevention and Treatment

基　　金：内蒙古自治区自然科学基金(2015MS08115,2020LH08031);内蒙古自治区卫生计生科研计划项目(201701066)。

摘　　要：肾细胞癌作为十种多发癌症之一,其发病率与死亡率二十多年来一直在增加。肾透明细胞癌(ccRCC)是其最常见的组织病理学亚型。环状核糖核酸(CircRNAs)是一种非编码核糖核酸,分布广泛,细胞功能多样化,并有器官及组织特异性表达模式。最近研究表明,CircRNAs在ccRCC中异常表达,作为其发生与发展的重要调节因子。目前CircRNAs调节ccRCC生物学行为的相关研究及机制较少。因此,本文主要就CircRNAs调节ccRCC生物学行为的研究进展进行叙述,并讨论其作为ccRCC早期诊断与预后的生物标志物及靶向治疗方面的潜力。Renal cell carcinoma is one of the ten multiple cancers,and its incidence rate and mortality rate have been increasing in more than 20 years.Clear cell renal cell carcinoma(ccRCC)is the most common histopathological subtype.Cyclic ribonucleic acids(circRNAs)are noncoding ribonucleic acids,which are widely distributed with diverse cellular functions and have organ-and tissue-specific expression patterns.Recent studies have shown that circRNAs are abnormally expressed in ccRCC and play an important role in the occurrence and development of ccRCC.However,there are few researches and related mechanisms of circRNAs regulating the biological behavior of ccRCC.Therefore,the paper mainly describes the research progress of circRNAs regulating the biological behavior of ccRCC and discusses its potential as a biomarker for early diagnosis and prognosis of ccRCC and targeted therapy.

关 键 词：环状核糖核酸 肾透明细胞癌 生物学行为 

分 类 号：R737.11[医药卫生—肿瘤]