Hippo信号通路在肝细胞癌诊治中作用的研究进展  

Research progress in role of Hippo signaling pathway in diagnosis and treatment for hepatocellular carcinoma

作　　者：马佳美 黄晓曦[1] MA Jiamei;HUANG Xiaoxi(Department of Gastroenterology,Affiliated Haikou Hospital of Xiangya School of Medicine,Central South University,Haikou 570208,China)

机构地区：[1]中南大学湘雅医学院附属海口医院消化内科,海口570208

出　　处：《中南大学学报（医学版）》2021年第6期637-643,共7页Journal of Central South University ：Medical Science

摘　　要：肝细胞癌(hepatocellular carcinoma,HCC)是全球最常见的恶性肿瘤之一,发病率和病死率均较高,然而其发生和发展机制仍不清楚。Hippo信号通路主要通过由核心分子构成的激酶链转导信号,抑制转录共激活因子入核,减少下游促增殖基因转录。近年来发现Hippo信号通路不仅调控肝发育和肝切除后的再生,而且与HCC的发生也密切相关。Hippo信号通路可调控HCC细胞增殖、转移、自噬、代谢重编程及免疫微环境,参与HCC对多种药物产生耐药的过程。研究Hippo信号通路在HCC中的作用对发现新的治疗靶点有重要意义。Hepatocellular carcinoma(HCC)is one of the most common malignant tumor worldwide,with high incidence and mortality.However,the exact mechanisms leading to HCC development remain unclear.The cores of the Hippo signaling pathway consist of a kinase cascade to transmit signals,which inhibits the transcriptional coactivator translocate into the nucleus and reduces the transcription of downstream proliferation-related genes.Hippo signaling pathway regulates liver development and regeneration after liver resection,and it is also related to the occurrence of HCC.The Hippo pathway regulates proliferation,apoptosis,metastasis,autophagy,metabolic reprogramming of HCC cells,affects the tumor immune microenvironment,and participates multiple-drug resistance.Further study on the role of Hippo signaling pathway in HCC is important to develop new therapeutic targets.

关 键 词：肝细胞癌 Hippo信号通路 Yes相关蛋白 含PDZ结合基序的转录共激活因子 治疗 

分 类 号：R735.7[医药卫生—肿瘤]