多原发性腹膜后脂肪肉瘤的治疗及预后  

Treatment and prognosis of retroperitoneal liposarcoma with multiple primary tumor

作　　者：苗成利[1] 黄梅 陈小兵 刘世博 邹博远 罗成华[1] Miao Chengli;Huang Mei;Chen Xiaobing y Liu Shibo;Zou Boyuan;Luo Chenghua(Department of Retroperitoneal Tumor Surgery,Peking University International Hospital,Beijing 102206,China)

机构地区：[1]北京大学国际医院腹膜后肿瘤外科,102206

出　　处：《中华肿瘤杂志》2021年第6期674-677,共4页Chinese Journal of Oncology

基　　金：北京大学国际医院重点课题(YN2017ZD03)。

摘　　要：目的探讨多原发腹膜后脂肪肉瘤的手术治疗及其预后情况。方法选取2017年5月至2019年12月于北京大学国际医院行腹膜肿瘤切除+腹膜后脂肪清扫的49例腹膜后脂肪肉瘤患者,收集患者的临床病理资料,分析腹膜后脂肪肉瘤的多原发情况及预后。结果 49例患者中,病理证实存在多个原发肿瘤(多发组)15例,非多个肿瘤(单发组)34例,多原发腹膜后脂肪肉瘤的发生率为30.6%(15/49)。高分化脂肪肉瘤和去分化脂肪肉瘤患者的疾病复发率分别为31.8%和44.4%,差异无统计学意义(P>0.05)。多发组和单发组患者的疾病复发率分别为40.0%和38.2%,差异无统计学意义(P>0.05)。全组49患者中,死亡5例。结论腹膜后脂肪肉瘤存在多原发性,行腹膜后脂肪切除术可使多原发患者的复发情况获益。Objective To investigate the multiple origin of retroperitoneal liposarcoma and its postoperative prognosis.Methods A total of 49 retroperitoneal liposarcoma patients underwent total(ipsilateral)retroperitoneal lipectomy in our center from May 2017 to December 2019 were recruited.Clinical data and the follow-up information were reviewed and the origin and prognosis were analyzed.Results A total of 15 patients were pathologically diagnosed as multiple primary cancer(MPC),the incidence rate of retroperitoneal liposarcoma with MPC was 30.6%(15/49),while other 34 cases was non-MPC.The postoperative recurrence rates of patients with high differentiation and de-differentiation retroperitoneal liposarcoma were 31.8%and 44.4%,without significant difference(P>0.05).The postoperative recurrence rates of MPC and non-MPC were 40.0%and 38.2%,without significant difference(P>0.05).Five cases died within the follow-up.Conclusion Retroperitoneal liposarcoma might origin form MPC,and total(ipsilateral)retroperitoneal lipectomy is recommended to reduce the recurrence rate.

关 键 词：腹膜后脂肪肉瘤 腹膜后脂肪切除术(单侧) 多原发性肿瘤 

分 类 号：R735.4[医药卫生—肿瘤]