2008-2014年鞍山市城区结直肠癌发病和死亡及生存分析  

Incidence,mortality and survival of colorectal cancer in Anshan City during 2008-2014

作　　者：张微微 王丽娟[1] 王肖琳 ZHANG Wei-wei;WANG Li-juan;WANG Xiao-lin(Chronic Disease Prevention and Control Section,Anshan Center for Disease Control and Prevention,Anshan 114000,China)

机构地区：[1]鞍山市疾病预防控制中心慢性病防制科,辽宁鞍山114000

出　　处：《中华肿瘤防治杂志》2021年第14期1061-1066,共6页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家肿瘤随访登记项目[卫办疾控发(2010)149号]。

摘　　要：目的分析鞍山市城区居民2008-2014年结直肠癌的发病率、死亡率和生存率变化趋势及流行特征。方法收集鞍山市肿瘤登记处2008-2014年的结直肠癌发病、死亡和生存资料,计算发病率、死亡率、累积率、截缩率和生存率等指标,标化率采用2000年全国人口普查标准人口年龄构成和Segi's世界标准人口年龄构成为标准。采用线性对数模型对发病率、死亡率进行拟合,计算年度变化百分比(APC);采用寿命表法计算生存率,病例随访时间截止到2019-12-31。2组数据生存率比较采用四格表χ^(2)检验。结果 2008-2014年结直肠癌新发病例4 730例,平均发病年龄为65.66岁,中位发病年龄67岁,位于恶性肿瘤发病第2位,粗发病率为45.66/10万,中标率为25.29/10万,世标率为24.88/10万;0~74岁累积率为2.95%,35~64岁截缩率为37.45/10万,发病粗率呈逐年上升趋势(APC为4.61%,F=22.00,P<0.05),世标率趋势无统计学意义(APC为-1.88%,F=4.48,P>0.05)。死亡病例1 949例,平均死亡年龄69.69岁,中位死亡年龄72岁,粗死亡率为18.81/10万,中标率为10.07/10万,世标率为9.92/10万;0~74岁累积率为1.04%,35~64岁截缩率为10.98/10万,粗死亡率呈上升趋势(APC为2.94%,F=7.63,P<0.05),标化率呈下降趋势(APC为-4.69%,F=13.41,P<0.05)。发病率和死亡率都随着年龄的增长呈上升趋势;所有指标男性均高于女性;结直肠癌3年生存率为62.24%,5年生存率为52.03%;2008-2014年结直肠癌3年(APC为-0.10%,F=0.01)、5年(APC为0.20,F=0.01)生存率变化均未见明显升降,差异均无统计学意义,均P>0.05。结论鞍山市城区居民结直肠癌发病率和死亡率总体上呈上升趋势,生存率不高但比较平稳,因此要加强结直肠癌早诊早治和预防控制工作。Objective To analyze the incidence rate,mortality and survival rate of colorectal cancer in Anshan city residents from 2008 to 2014 years.Methods The incidence,mortality and survival data of colorectal cancer in Anshan City Cancer Registry from 2008 to 2014 years were collected.The incidence rate,mortality rate,cumulative rate,cut rate and survival rate were calculated.The standardized rate was based on the standard population age composition of National Population Census in 2000 and SEGI’s world standard population age composition.A linear logarithmic model was used to calculate the annual percentage change(APC)of incidence rate and mortality rate.The life table method was used to calculate the survival rate,and the follow-up time was up to December 31,2019.The survival rates of the two groups were compared by chi square test.Results From 2008 to 2014,there were 4730 new cases of colorectal cancer,with an average age of65.66 years old and the median age of onset was 67 years,ranking second in the incidence of malignant tumors.The crude incidence rate was 45.66/105,the Chinese stard and rate was 25.29/105,the world standard rate was 24.88/105,the cumulative rate of 0-74 years old was 2.95%,the amputation rate of 35-64 years old was 37.45/105,and the incidence of rash increased year by year(APC=4.61%,F=22.00,P<0.05).The trend of world standard rate was not statistically significant(APC=-1.88%,F=4.48,P>0.05).There were 1949 deaths from colorectal cancer,the average age of death was 69.69 years old and the median age of death was 72 years,the crude mortality rate was 18.81/105,the Chinese standardized rate was 10.07/105 and the world standard rate was 9.92/105;the cumulative rate of 0-74 years old was1.04%,and the amputation rate of 35-64 years old was 10.98/105.The crude mortality rate showed an upward trend(APC=2.94%,F=7.63,P<0.05),and the standardized rate showed a downward trend(APC=-4.69%,F=13.41,P<0.05);The incidence rate and mortality rate increased with age.All the indicators in males were higher than that

关 键 词：结直肠癌 发病率 死亡率 生存率 鞍山 

分 类 号：R735.3[医药卫生—肿瘤]