分析不同TOAST亚型急性脑梗死患者Treg比例及hs-CRP水平的差异及其与脑梗死后感染风险的关系  

Analyze Differences of Treg%and hs-CRP levels in Patients with Acute Cerebral Infarction of Different Toast Subtypes and Their Relationship with the Risk of Infection after Cerebral Infarction

作　　者：王廉昌 王英杰[1] 闫红静 索洪江 赵会利 Wang Lianchang;Wang Yingjie;Yan Hongjing;Suo Hongjiang;Zhao Huili(Department of Neurology,The First Hospital of Handan,Handan 056002,Hebei Province,China)

机构地区：[1]邯郸市第一医院神经内三科,河北省邯郸市056002

出　　处：《中国病案》2021年第6期88-92,共5页Chinese Medical Record

摘　　要：目的探究不同TOAST亚型急性脑梗死患者调节性T细胞比例及超敏C反应蛋白水平的差异及其与脑梗死后感染风险的关系.方法选取2018年10月1日-2020年10月1日就诊于某院的175例ACI患者,根据TOAST病因学分型分为大动脉粥样硬化型组82例、心源性栓塞型组43例、小动脉闭塞型组50例,另选取同期本院体检的健康人群50例作为对照组.比较各组Treg%、hsCRP水平以及分析其与脑梗死后感染风险的关系.结果与对照组(7.42±1.63)比较,LAA组Treg%(6.59±1.19)显著降低,CE组Treg比例(8.99±1.96)显著升高,各TOAST亚型组hsCRP水平显著升高,与LAA组[(6.59±1.19)、(2.79±0.75)mg/L]比较,CE组Treg%(8.99±1.96)、hs-CRP水平(6.62±1.83)mg/L显著升高,差异有统计学意义,P<0.05,SAO组(7.83±1.34)与对照组Treg%(7.42±1.63)比较差异无统计学意义,P>0.05;与未感染组患者[(7.19±1.62)、(1.52±0.76)mg/L]比较,感染组Treg%(8.12±1.59)、hsCRP水平(8.96±2.03)mg/L显著升高,差异有统计学意义,P<0.05;Treg比例(r=0.223,P=0.024)、hs-CRP水平(r=0.316,P=0.003)与脑梗死后感染呈正相关.结论不同TOAST亚型ACI患者Treg%及hsCRP水平存在一定的差异,同时其与脑梗死后感染风险呈正相关,对临床治疗ACI具有着较高的参考价值.Objective To explore the difference of regulatory T cell percentage(Treg%)and hypersensitive C-reactive protein(hs-CRP)levels in patients with acute cerebral infarction(ACI)of different toast subtypes and their relationship with infection risk after cerebral infarction.Methods 175 patients with ACI from October 1,2018 to October 1,2020 in our hospital were selected and divided into large artery atherosclerosis(LAA)group(82 cases),cardiac embolism(CE)group(43 cases)and small artery occlusion(small artery occlusion)group according to toast etiological classification In addition,50 healthy people who had physical examination in our hospital during the same period were selected as the control group.The levels of Treg%,hs-CRP and Pearson correlation coefficient were compared,and the relationship between Treg%,hsCRP and infection risk after cerebral infarction was analyzed.Results Compared with the control group(7.42±1.63),Treg%(6.59±1.19)in LAA group was significantly decreased,Treg%(8.99±1.96)in CE group was significantly increased,hsCRP level in each toast subtype group was significantly increased.Compared with LAA Group[(6.59±1.19),(2.79±0.75)mg/l],Treg%(8.99±1.96)and hs-CRP level in CE group(6.62±1.83)mg/L were significantly increased(P<0.05)(Compared with the control group[(7.83±1.34)vs.(7.42±1.63),there was no significant difference(P>0.05);compared with the non infected group[(7.19±1.62),(1.52±0.76)mg/l],the levels of Treg%(8.12±1.59)and hsCRP(8.96±2.03)mg/L in the infected group were significantly increased(P<0.05);the levels of Treg%(r=0.223,P<0.05),024),hs-CRP level(r=0.316,P=0.003)were positively correlated with infection after cerebral infarction.Conclusion The levels of Treg%and hsCRP in patients with ACI of different toast subtypes are different,and they are positively correlated with the risk of infection after cerebral infarction,which has a high reference value for clinical treatment of ACI.

关 键 词：TOAST亚型 急性脑梗死 调节性T细胞比例 超敏C反应蛋白 脑梗死后感染 

分 类 号：R743.33[医药卫生—神经病学与精神病学]