Alcohol Cessation in Late Life is Associated with Lower Risk of Cognitive Impairment among the Older Adults in China  

作　　者：ZHANG Xiao Chang GAO Xiang LYU Yue Bin ZHOU Jin Hui WEI Yuan YIN Zhao Xue MA Ji Xiang MAO Chen SHI Xiao Ming 

机构地区：[1]National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China [2]Division of Non-communicable Disease and Ageing Health Management,Chinese Center for Disease Control and Prevention,Beijing 102206,China [3]Nutritional Epidemiology Lab,Pennsylvania State University,Philadelphia 16801,PA,USA [4]Center for Disease Control and Prevention of Shandong Province,Jinan 250014,Shandong,China [5]Division of Epidemiology,School of Public Health,Southern Medical University,Guangzhou 510515,Guangdong,China [6]Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing 211166,Jiangsu,China

出　　处：《Biomedical and Environmental Sciences》2021年第7期509-519,共11页生物医学与环境科学（英文版）

基　　金：supported by National Natural Sciences Foundation of China[grant numbers 81941023,81872707,81573247,and 71490732];National Science and Technology Planning Project[grant number 2018YFC2000300];the US National Institute of Aging/United Nations Fund for Population Activities[2P01AG031719]。

摘　　要：Objective Evidence regarding alcohol consumption and cognitive impairment is controversial.Whether cessation of drinking alcohol by non-dependent drinkers alters the risk of cognitive impairment remains unknown.This study prospectively evaluated the potential association between the history of lifetime alcohol cessation and risk of cognitive impairment.Methods This study included 15,758 participants age 65 years or older,selected from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)that covered 23 provinces in China.Current alcohol use status,duration of alcohol cessation,and alcohol consumption before abstinence were self-reported by participants;cognitive function was evaluated using Mini-mental State Examination(MMSE).Causespecific hazard models and restricted cubic splines were applied to estimate the effect of alcohol use on cognitive impairment.Results Among the 15,758 participants,mean(±SD)age was 82.8 years(±11.9 years),and 7,199(45.7%)were males.During a mean of 3.9 years of follow-up,3,404 cases were identified as cognitive impairment.Compared with current drinkers,alcohol cessation of five to nine years[adjusted HR,0.79(95%CI:0.66-0.96)]and more than nine years[adjusted HR,0.82(95%CI:0.69-0.98)]were associated with lower risk of cognitive impairment.Conclusion A longer duration of alcohol cessation was associated with a lower risk of cognitive impairment assessed by MMSE.Alcohol cessation is never late for older adults to prevent cognitive impairment.

关 键 词：COGNITION Alcohol abstinence Alcohol drinking EPIDEMIOLOGY AGING 

分 类 号：R163[医药卫生—公共卫生与预防医学] R749.1