Nrf2/ARE信号通路及其在肿瘤发生发展中作用的研究进展  

Progress of Nrf2/ARE signaling pathway and tumor genesis and development

作　　者：邰宵辉 张玲芳[1] 张旭霞[1] 刘乐[1] 薛丽[1] 党春艳 李红玲[1] TAI Xiaohui;ZHANG Lingfang;ZHANG Xuxia;LIU Le;XUE Li;DANG Chunyan;LI Hongling(Department of Oncology,Gansu Provincial Hospital,Gansu Lanzhou 730000,China)

机构地区：[1]甘肃省人民医院肿瘤内科,甘肃兰州730000

出　　处：《现代肿瘤医学》2021年第17期3113-3116,共4页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81760537,81560498);甘肃省人民医院院内科研基金项目(编号:18GSSY4-30)。

摘　　要：Nrf2/ARE信号通路作为机体抗氧化应激的重要保护通路,主要受Keap1的调控,组合成Keap1-Nrf2/ARE通路,其在肿瘤发生、发展中起着重要作用,也是介导组织癌变的关键通路,有防癌、促癌的双向作用。因此,对Nrf2/ARE信号通路的进一步研究能为了解肿瘤的发病机制、寻求有效的诊断和治疗方法提供有力帮助。本文就Nrf2/ARE信号通路在肿瘤发生发展中的研究进展做一综述。Nrf2/ARE signaling pathway,as an important protective pathway of the body against oxidative stress,is mainly regulated by Keap1 and combined into the KEAP1-Nrf2/ARE pathway,which plays an important role in the occurrence and development of tumors,and is also a key pathway mediating tissue canceration.It has a two-way effect of cancer prevention and cancer promotion.Therefore,further research on Nrf2/ARE signaling pathway is likely to provide powerful help for understanding the pathogenesis of tumors and seeking for effective diagnosis and treatment.This article reviews the research progress of Nrf2/ARE signaling pathway and tumor genesis and development.

关 键 词：肿瘤 Nrf2/ARE信号通路 氧化应激 

分 类 号：R730[医药卫生—肿瘤]