葡萄糖神经酰胺及其代谢酶与肝脏疾病的关系  

Relationship of Glucosylceramide and Its Metabolic Enzymes with Liver Disease

作　　者：魏喜生 甘建[1] 毛小荣 李俊峰[1,2,3] WEI Xisheng;GAN Jian;MAO Xiaorong;LI Junfeng(The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Institute of Infectious Diseases,the First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Infectious Diseases,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院传染病研究室,兰州730000 [3]兰州大学第一医院感染科,兰州730000

出　　处：《医学综述》2021年第16期3173-3177,共5页Medical Recapitulate

基　　金：国家自然科学基金(81800528);甘肃省科技计划项目(20JR5RA364);甘肃省重点研发计划(20YF2FA011)。

摘　　要：真核细胞膜及细胞器膜富含脂质,脂质不仅是细胞膜和细胞器膜的结构载体,细胞的许多功能均离不开脂质。脂质是一类具有重要结构和功能的化学物质,在多种肝脏疾病中扮演重要角色。糖鞘脂是脂质中重要的一类分子,其以葡萄糖神经酰胺(GC)为代谢枢纽,而GC是由葡萄糖神经酰胺合成酶(GCS)催化神经酰胺产生。GCS作为糖鞘脂合成代谢的关键酶,其活性直接影响细胞内GC水平,进而影响体内细胞的功能,并可导致相关疾病的发生。然而,目前关于GCS在肝脏疾病中作用机制的研究较少。因此,深入了解GC及其代谢酶的生物学功能将有助于揭示相关肝脏疾病的发病机制。Eukaryotic cell membranes and organelle membranes are rich in lipids,which are not only the structural carriers of cell membranes and organelle membranes,but also inseparable parts for multiple functions of cells.Lipids are a class of chemical substances with important structures and functions,playing an important role in multiple liver diseases.Glycosphingolipids are an important class of molecules in lipids,with glucosylceramide(GC)as the metabolic hub,which is produced by catalyzing ceramide by glucosylceramide synthase(GCS).GCS,as a key enzyme in glycosphingolipid anabolism,its activity directly affects the level of GC in cells which in turn affects the function of cells and may eventually lead to related diseases.However,there are few studies on the mechanisms of GCS in liver diseases.Therefore,in-depth understanding of the biological functions of GC and its metabolic enzymes will help to reveal the pathogenesis of related liver diseases.

关 键 词：免疫性肝损伤 病毒性肝炎 肝纤维化 肝癌 葡萄糖神经酰胺 糖鞘脂 葡萄糖神经酰胺合成酶 

分 类 号：R575[医药卫生—消化系统]