不同Y染色体微缺失类型对生精功能的影响研究  

Impacts of different Y chromosome microdeletions on spermatogenesis

作　　者：朱来晴 汪珣 孙国海 周雪[1] 韩友峰[1] 石亮[1] ZHU Lai-qing;WANG Xun;SUN Guo-hai;ZHOU Xue;HAN You-feng;SHI Liang(Laboratory of Andrology,Drum Tower Hospital,Nanjing University School of Medicine,Nanjing,Jiangsu 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院男科实验室,江苏南京210008

出　　处：《中华男科学杂志》2021年第6期517-521,共5页National Journal of Andrology

摘　　要：目的:回顾分析Y染色体微缺失患者的精液参数以探究其对男性生精功能的影响。方法:从我院就诊并检测Y染色体微缺失的患者中筛选出Y染色体微缺失阳性的男性不育患者151例,并回顾分析这151例患者的精液参数以及对生精功能的影响。结果:筛查出的151例Y染色体微缺失阳性的男性不育患者中AZFc、AZFb、AZFa、AZFa+c、AZFb+c、AZFc+d、AZFb+c+d、AZFa+b+c+d、sY127、sY134、sY86缺失比例各占66.89%、3.97%、3.31%、0.66%、3.97%、0.66%、8.61%、7.95%、1.99%、0.66%、0.66%;其中有48例无精子症,74例隐匿精子症,28例少弱精子症,1例弱畸精子症。结论:Y染色体微缺失会导致男性精子质量下降以及不同的缺失类型对生精功能影响也不同。Objective:To study the semen parameters of the patients with Y chromosome microdeletions and their impacts on the spermatogenesis of the patients.Methods:We selected 151 male infertility patients with Y chromosome microdeletions from those diagnosed and treated in our hospital and retrospectively analyzed the influence of their semen parameters on the spermatogenic function.Results:Of the 151 cases of Y chromosome microdeletions,AZFc was involved in 102(66.89%),AZFb in 6(3.97%),AZFa in 5(3.31%),AZFa+c in 1(0.66%),AZFb+c in 6(3.97%),AZFc+d in 1(0.66%),AZFb+c+d in 13(8.61%),AZFa+b+c+d in 12(7.95%),sY127 in 3(1.99%),sY134 in 1(0.66%)and sY86 in 1(0.66%).Among the total number of the infertility patients,48(31.78%)were diagnosed with azoospermia,74(49%)with cryptozoospermia,28(18.54)with oligoasthenozoospermia and 1(0.66%)with asthenoteratozoospermia.Conclusion:Y chromosome microdeletions may lead to decreased sperm quality,and different types of deletion have different impacts on the spermatogenic function of the patients.

关 键 词：Y染色体微缺失 精液参数 生精功能 

分 类 号：R698.2[医药卫生—泌尿科学]