KRAB相关蛋白1的功能及其在疾病中的研究进展  

Functions of KAP1 and Its Research Progress in Diseases

作　　者：严天晴 马萍 齐素华 王婉 YAN Tianqing;MA Ping;QI Suhua;WANG Wan(School of Medical Technology,Xuzhou Medical University,Xuzhou Key Laboratory of Inspection and Diagnostics,Xuzhou 221004,China;Department of Laboratory Medicine,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China)

机构地区：[1]徐州医科大学医学技术学院,徐州市检验诊断学重点实验室,徐州221004 [2]徐州医科大学附属医院检验医学科,徐州221002

出　　处：《中国细胞生物学学报》2021年第7期1543-1549,共7页Chinese Journal of Cell Biology

基　　金：徐州市科技计划项目(批准号:KC18052);江苏省高等学校自然科学研究面上项目(批准号:20KJB310018)资助的课题。

摘　　要：KRAB相关蛋白1(KRAB-associated protein 1,KAP1)又称转录中介因子1β(transcriptional intermediary factor 1β,TIF1β),也称三重基序蛋白28(tripartite motif-containing protein 28,TRIM28),是许多基因转录调控复合体中的支架分子,参与免疫调节、胚胎早期发育、病毒复制、DNA损伤反应、肿瘤发生发展等许多生理病理过程的调控。KAP1存在磷酸化、乙酰化等多种翻译后修饰且参与蛋白质泛素化、类泛素化修饰和DNA甲基化、组蛋白甲基化、去乙酰化修饰,这对KAP1功能的发挥具有重要作用。该文综述了KAP1的功能及其在疾病中的研究进展,以期为KAP1相关疾病的分子治疗提供指导。KAP1(KRAB-associated protein 1),also called TIF1β(transcriptional intermediary factor 1β)or TRIM28(tripartite motif-containing protein 28),is a scaffold molecule involved in formation of many gene transcriptional regulatory complexes.KAP1 participates in many physiological and pathological processes,such as immune response,early embryonic development and stem gene expression,DNA damage repairation,tumor development and so on.KAP1 has a variety of post-translational modifications,such as phosphorylation and acetylation,and is involved in protein ubiquitination,DNA methylation,histone methylation,and deacetylation,which plays an important role in the function of KAP1.This paper summarizes the function of KAP1 and its research progress in diseases,hoping to provide guidance for molecular therapy with KAP1 as the target.

关 键 词：KRAB相关蛋白1 翻译后修饰 疾病 

分 类 号：R363[医药卫生—病理学]