干细胞成像技术在肝脏疾病诊疗中的应用进展  

Research progress of stem cells imaging technology in the diagnosis and treatment of liver diseases

作　　者：刘凤永[1] 施明 王福生 Liu Fengyong;Shi Ming;Wang Fusheng(Chinese PLA General Hospital,Chinese PLA Medical School,Beijing 100853,China;Senior Department of Infectious Diseases,the Fifth Medical Center of PLA General Hospital,Beijing 100039,China)

机构地区：[1]解放军总医院解放军医学院,北京100853 [2]解放军总医院第五医学中心感染病医学部,北京100039

出　　处：《中华肝胆外科杂志》2021年第8期630-633,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：肝脏疾病是造成人类疾病死亡的主要原因之一。重症肝脏疾病(例如晚期肝硬化、肝细胞癌等)的最有效治疗方法是原位肝移植。然而,供体有限、免疫排斥等因素限制了肝移植的应用及开展。近几年,具备多向分化能力的干细胞疗法在治疗肝病方面展现出潜在的应用价值。然而,干细胞疗法的作用机制目前尚未有统一的认识。体内细胞成像技术可以更好地了解干细胞的行为和命运,能够对干细胞的迁移、分布、增殖及分化进行无创性活体示踪,是研究干细胞治疗肝病作用机制的重要技术手段。因此,本文将对干细胞活体成像技术在肝病干细胞诊疗领域的最新研究进展进行综述。Liver disease is one of the main causes of human deaths in the world.Orthotopic liver transplantation is the most effective treatment for severe liver diseases,such as liver cirrhosis,hepatocellular carcinoma,etc.However,liver transplantation was limited because of donors shortage,and immunological.In recent years,stem cell therapy with the ability of multi-directional differentiation has potential application value in the treatment of patients with liver diseases.However,the mechanisms of stem cell therapy have not yet been fully understood.Stem cells can be detected under in vivo cell imaging.It can noninvasively trace the distribution,migration,proliferation and differentiation of stem cells,and it is an important link to study the mechanism of stem cells in the treatment of liver diseases.Therefore,this review briefly introduces the latest research progress of stem cell in vivo imaging techniques in the field of stem cell diagnosis and treatment of liver diseases.

关 键 词：肝脏疾病 干细胞 活体成像技术 

分 类 号：R575[医药卫生—消化系统]