Emerging Role of PD-1 in the Central Nervous System and Brain Diseases  

作　　者：Junli Zhao Alexus Roberts Zilong Wang Justin Savage Ru-Rong Ji 

机构地区：[1]Department of Anesthesiology,Duke University Medical Center,Durham,27710,USA [2]Department of Biology,Duke University Medical Center,Durham,27710,USA [3]Department of Neurobiology,Duke University Medical Center,Durham,27710,USA [4]Department of Cell Biology,Duke University Medical Center,Durham,27710,USA

出　　处：《Neuroscience Bulletin》2021年第8期1188-1202,共15页神经科学通报（英文版）

基　　金：The work related to this review was partially supported by Duke University Fund.

摘　　要：Programmed cell death protein 1(PD-1)is an immune checkpoint modulator and a major target of immunotherapy as anti-PD-1 monoclonal antibodies have demonstrated remarkable efficacy in cancer treatment.Accumulating evidence suggests an important role of PD-1 in the central nervous system(CNS).PD-1 has been implicated in CNS disorders such as brain tumors,Alzheimer’s disease,ischemic stroke,spinal cord injury,multiple sclerosis,cognitive function,and pain.PD-1 signaling suppresses the CNS immune response via resident microglia and infiltrating peripheral immune cells.Notably,PD-1 is also widely expressed in neurons and suppresses neuronal activity via downstream Src homology 2 domain-containing protein tyrosine phosphatase 1 and modulation of ion channel function.An improved understanding of PD-1 signaling in the cross-talk between glial cells,neurons,and peripheral immune cells in the CNS will shed light on immunomodulation,neuromodulation,and novel strategies for treating brain diseases.

关 键 词：PD-1 Central nervous system Immune checkpoint IMMUNOTHERAPY NEUROTHERAPY 

分 类 号：R338[医药卫生—人体生理学]