Single-domain antibodies for radio nuclear imaging and therapy of esophageal squamous cell carcinoma:a narrative review  

作　　者：Huifang Liu Xu Nie Zhenchao Tian Dan Chen Xueli Chen Qi Zeng Xinyi Xu 

机构地区：[1]Engineering Research Center of Molecular and Neuroimaging,Ministry of Education,School of Life Science and Technology,Xidian University,Xi’an,Shaanxi Province,China

出　　处：《Journal of Bio-X Research》2020年第4期135-143,共9页生物组学研究杂志（英文）

基　　金：supported,in part,by the National Key Research&Development Program of China(No.2018YFC0910600);the National Natural Science Foundation of China(Nos.81871397,81701853,81627807);the Natural Science Basic Research Plan in Shaanxi Province of China(Nos.2019JQ-519,2019JQ-201,2019JQ-045);the Fundamental Research Funds for the Central Universities(No.JB191209).

摘　　要：Single-domain antibodies have the characteristics of small molecular weight,strong tissue penetration,and high affinity,and are widely used to construct molecular probes for disease diagnosis and treatment.This article reviews molecular imaging studies including positron emission tomography(PET),single-photon emission computed tomography/computed tomography(CT),PET/CT,and fluorescent imaging of molecular probes composed of single-domain antibodies against eight esophageal squamous cell carcinoma biological targets.These 8 targets are highly expressed on the membrane of esophageal squamous cell carcinoma cells and include epidermal growth factor receptor,human epidermal growth factor receptor 2,human epidermal growth factor receptor 3,hepatocyte growth factor receptor,vascular endothelial growth factor receptor 2,chemokine receptor 4,chemokine receptor 7,and carcinoembryonic antigen.The current problems and solutions are also discussed to provide a reference for future design of molecular imaging probes targeting esophageal squamous cell carcinoma.

关 键 词：esophageal squamous cell carcinoma hepatocyte growth factor receptor human epidermal growth factor receptor molecular imaging single-domain antibody 

分 类 号：R73[医药卫生—肿瘤]