综合脑保护治疗在急性脑梗死中的应用价值  

Study on the application value of comprehensive cerebral protection treatment in acute cerebral infarction

作　　者：刘仲秋 LIU Zhongqiu(Department of Neurology,the Juye County People's Hospital,Shandong,Juye 274900,China)

机构地区：[1]山东省巨野县人民医院神经内科,山东巨野274900

出　　处：《中国医药科学》2021年第15期219-221,226,共4页China Medicine And Pharmacy

摘　　要：目的探究综合脑保护治疗在急性脑梗死中的应用价值。方法选取2019年1月至2020年12月在山东省巨野县人民医院治疗的急性脑梗死患者90例,按照随机数字表法分为观察组和对照组,每组各45例。两组均进行了标准治疗,观察组在此基础上进行综合脑保护治疗。比较两组脑氧代谢、血液流变学及神经功能指标的变化差异。结果与对照组比较,观察组治疗后脑氧代谢得到明显改善,具有更高的动脉-颈内静脉血氧含量差(Da-jvO_(2))、血氧饱和度(SpO_(2))和更低的颈内静脉球部氧饱和度(SjvO_(2)),差异有统计学意义(P<0.05)。两组治疗后血液流变学均明显改善,且观察组全血黏度、全血比黏度和血浆黏度均明显低于对照组,差异有统计学意义(P<0.05)。与对照组比较,观察组治疗后NIHSS评分明显更低,而Barthel指数评定量表(BI)评分明显更高,差异有统计学意义(P<0.05)。结论综合脑保护治疗可有效改善急性脑梗死患者的脑氧代谢、血液流变学及神经功能,对改善患者预后具有重要作用。Objective To investigate the application value of comprehensive cerebral protection treatment in acute cerebral infarction.Methods A total of 90 patients with acute cerebral infarction treated in Juye County People's Hospital from January 2019 to December 2020 were selected and randomly divided into the observation group and the control group according to the random number table method,with 45 cases in each group.Both groups received standard treatment,and the observation group also received comprehensive cerebral protection treatment on this basis.The differences in the indices changes of cerebral oxygen metabolism,hemorheology and neurological function between the two groups were compared.Results Compared with the control group,the cerebral oxygen metabolism was more significantly improved in the observation group after treatment,with higher arterial-internal jugular venous oxygen content difference(Da-jvO_(2))and blood oxygen saturation(SpO_(2))and lower jugular bulb venous oxygen saturation(SjvO_(2)),and the differences were statistically significant(P<0.05).The hemorheology indices were significantly improved in both groups after treatment,and whole blood viscosity,whole blood contrast viscosity and plasma viscosity in the observation group were all significantly lower than those in the control group,with statistically significant differences(P<0.05).Compared with the control group,the scores of the NIHSS were significantly lower and the scores of the Barthel Index(BI)were significantly higher in the observation group after treatment,with statistically significant differences(P<0.05).Conclusion Comprehensive cerebral protection treatment can effectively improve cerebral oxygen metabolism,hemorheology and neurological function in patients with acute cerebral infarction,which has an important role in improving the prognosis of patients.

关 键 词：急性脑梗死 脑保护 综合治疗 脑氧代谢 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]