纳米碳联合亚甲蓝示踪前哨淋巴结在腹腔镜结直肠癌根治术中的应用  

Application of nano-carbon combined with methylene blue tracing sentinel lymph nodes in laparoscopic radical resection of colorectal cancer

作　　者：钟隆柱 宿茂伟 赵荣 付秀华 刘伟峰 ZHONG Longzhu;SU Maowei;ZHAO Rong;FU Xiuhua;LIU Weifeng(Department of General Surgery,Liwan Central Hospital of Guangzhou,Guangdong,Guangzhou 510150,China)

机构地区：[1]广州市荔湾中心医院普外科,广东广州510150

出　　处：《中国医药科学》2021年第16期187-190,共4页China Medicine And Pharmacy

基　　金：广东省医学科学技术研究基金项目(B2018002);广东省广州市荔湾区科技计划项目(202004025)。

摘　　要：目的观察纳米碳联合亚甲蓝示踪前哨淋巴结在腹腔镜结直肠癌根治术中的应用及研究分析。方法选取2016年12月至2019年12月在广州市荔湾中心医院行腹腔镜结直肠癌手术的患者68例,随机分成两组,每组各34例,纳米碳联合亚甲蓝示踪前哨淋巴结腹腔镜根治术(试验组)和腹腔镜根治术(对照组),随访至术后。对两组的性别、年龄、癌胚抗原(CEA)、手术的时间、术中出血量、术后并发症、肿瘤的大小、总淋巴结检出数及转移淋巴结数、前哨淋巴结检出数及前哨淋巴结转移率进行比较。结果试验组患者手术时间短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05)。试验组术后并发症发生率为2.94%,稍低于对照组的8.82%,两组肿瘤大小相比,差异无统计学意义(P>0.05)。试验组总淋巴结检出数及转移淋巴结数、前哨淋巴结检出数及前哨淋巴结转移率高于对照组,差异有统计学意义(P<0.05)。结论在腹腔镜结直肠癌根治术中,应用纳米碳联合亚甲蓝示踪前哨淋巴结,可较为准确的预测区域淋巴结转移状况,临床指导意义较为重大。Objective To observe the application of nano-carbon combined with methylene blue tracing sentinel lymph nodes in laparoscopic radical resection of colorectal cancer.Methods A total of 68 patients undergoing laparoscopic colorectal cancer surgery admitted to Liwan Central Hospital of Guangzhou from December 2016 to December 2019 were randomly divided into the experimental group(n=34)and the control group(n=34).The experimental group was treated with nano-carbon combined with methylene blue tracing sentinel lymph nodes in laparoscopic radical resection of colorectal cancer,while the control group was treated with laparoscopic radical resection.Meanwhile,they were followed up to the postoperative period.The gender,age,carcino-embryonic antigen(CEA),operation time,intraoperative hemorrhage volume,incidence of postoperative complications,tumor size,the total number of lymph nodes detected,the number of metastatic lymph nodes,the number of sentinel lymph nodes detected,and the rate of sentinel lymph node metastasis were compared between the two groups.Results The operation time of the experimental group was shorter than that of the control group,the intraoperative hemorrhage volume was less than that of the control group,with statistically significant differences(P<0.05).Meanwhile,the incidence of postoperative complication of the experimental group was 2.94%,which was slightly lower than 8.82%of the control group.However,there was no statistically significant difference in tumor sizes between the two groups(P>0.05).The total number of lymph nodes detected,the number of metastatic lymph nodes,the number of sentinel lymph nodes detected and the rate of sentinel lymph node metastasis in the experimental group were significantly higher than those in the control group,with statistically significant differences(P<0.05).Conclusion In laparoscopic radical resection of colorectal cancer,the application of nano-carbon combined with methylene blue tracing sentinel lymph nodes can accurately predict regional lymph nodes metastasi

关 键 词：纳米碳 亚甲蓝 联合使用 示踪前哨淋巴结 腹腔镜 结直肠癌根治术 

分 类 号：R735.34[医药卫生—肿瘤]