增氧型纳米递送系统用于光动力治疗的研究进展  

Advances of research on oxygen-enhancing nano-delivery system for photodynamic therapy

作　　者：孙晨凯 陈鑫[1] 程皓 张向泽 杨筱钰 周建平[1,2,3] 丁杨 SUN Chenkai;CHEN Xin;CHENG Hao;ZHANG Xiangze;YANG Xiaoyu;ZHOU Jianping;DING Yang(Department of Pharmaceutics&State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009;Ministry of Education Key Laboratory of Drug Quality Control and Pharmacovigilance,China Pharmaceutical University,Nanjing 210009;NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients,Nanjing 210009,China)

机构地区：[1]中国药科大学药剂系,天然药物活性组分与药效国家重点实验室,南京210009 [2]中国药科大学,药物质量与安全预警教育部重点实验室,南京210009 [3]国家药品监督管理局药物制剂及辅料研究与评价重点实验室,南京210009

出　　处：《中国药科大学学报》2021年第4期387-397,共11页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81872819,No.82073401,No.82073795)。

摘　　要：光动力治疗是一种新型非侵入性治疗手段,其原理是光敏剂经激光触发后将能量转移至氧气,生成具有细胞毒性的单线态氧,从而诱导肿瘤细胞发生凋亡或坏死。作为一种氧依赖性治疗方式,光动力治疗的抗肿瘤效果明显受限于实体瘤的乏氧微环境。因此,逆转并改善肿瘤组织的缺氧情况可显著增强光动力治疗效果。本文重点讨论纳米递送系统介导的肿瘤增氧策略的研究进展,包括氧气直接递送策略、酶催化产氧递送策略、响应型材料原位产氧递送策略和微生物体供氧递送策略,以提高光动力治疗抗肿瘤效果,为进一步研究增氧型光动力治疗纳米给药系统提供了新思路和新方案。Photodynamic therapy,a new type of non-invasive treatment,is based on the principle that the photosensitizer excited by laser can transfer energy to oxygen,which generates cytotoxic singlet oxygen and thus induce tumor cell apoptosis or necrosis.As an oxygen-dependent therapy,the antitumor effect of photodynamic therapy is obviously limited by hypoxia environment of solid tumor tissue.Therefore,reversing and improving the hypoxia of tumor tissue can significantly enhance the efficacy of photodynamic therapy.This review focuses on the progress of tumor oxygenation strategy mediated by nano-delivery system,including direct oxygen delivery strategies,catalytic oxygen production strategies,responsive material in situ oxygen supply strategies and microorganism oxygen supply strategies,aiming to improve the antitumor effect of photodynamic therapy.It provides new ideas and new approaches for further study of oxygen-enchancing nano-delivery system for photodynamic therapy.

关 键 词：纳米递送系统 氧气直接输送 原位产氧供氧 微生物体供氧 光动力学增效治疗 进展 

分 类 号：R730.5[医药卫生—肿瘤]