Amphichoterpenoids A-C,unprecedented picoline-derived meroterpenoids from the ascidian-derived fungus Amphichorda felina SYSU-MS7908  

作　　者：Minghua Jiang Zhenger Wu Qilin Wu Huimin Yin Heng Guo Siwen Yuan Zhaoming Liu Senhua Chen Lan Liu 

机构地区：[1]School of Marine Sciences,Sun Yat-sen University,Guangzhou 510006,China [2]Southern Laboratory of Ocean Science and Engineering(Guangdong,Zhuhai),Zhuhai 519000,China [3]South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center,Guangzhou 510006,China [4]State Key Laboratory of Applied Microbiology Southern China,Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application,Guangdong Open Laboratory of Applied Microbiology,Guangdong Institute of Microbiology,Guangdong Academy of Sciences,Guangzhou 510070,China

出　　处：《Chinese Chemical Letters》2021年第6期1893-1896,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.41806155);the Guangdong MEPP Fund(No.GDOE(2019)A21);the National Key R&D Program of China(No.2019YFC0312501);the Natural Science Foundation of Guangdong Province(No.2018A030310304);the Key-Area Research and Development Program of Guangdong Province(No.2020B1111030005)for generous support。

摘　　要：Amphichoterpenoids A-C(1-3),unprecedented picoline-derived meroterpenoids possessing a pyrano[3,2-c]pyridinyl-g-pyranone scaffold,were characterized from the ascidian-derived fungus Amphichorda felina SYSU-MS7908.Their structures were elucidated by spectroscopic methods,X-ray diffraction and electronic circular dichroism(ECD)calculations.A plausible biosynthetic pathway was proposed.The isolated compounds displayed moderate inhibitory activity against acetylcholinesterase with 50%inhibiting concentration(IC_(50))values of 18.8-53.2 mmol/L.

关 键 词：Fungal meroterpenoid PICOLINE Amphichorda felina Encapsulated nanodroplet crystallization ACETYLCHOLINESTERASE 

分 类 号：O629.61[理学—有机化学]