Alum colloid encapsulated insideβ-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine  

作　　者：Yonghui Liu Mingjing Li Haomiao Zhu Zhe Jing Xiaona Yin Kun Wang Zhangyong Hong Wei Zhao 

机构地区：[1]State Key Laboratory of Medicinal Chemical Biology,College of Pharmacy and KLMDASR of Tianjin,Nankai University,Tianjin 300353,China [2]State Key Laboratory of Medicinal Chemical Biology&Tianjin Key Laboratory of Protein Sciences,College of Life Sciences,Nankai University,Tianjin 300071,China

出　　处：《Chinese Chemical Letters》2021年第6期1963-1966,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.22077068);the National Key R&D Program of China(No.2018YFA0507204);the NCC Fund(No.NCC2020FH12);the Natural Science Foundation of Tianjin(No.19JCQNJC05300);the Fundamental Research Funds for the Central Universities。

摘　　要：We have developed a MUC1 antigen-based antitumor vaccine loaded on alum colloid encapsulated insideβ-glucan particles(GP-Al).The constructed vaccine induced strong MUC1 antigen specific Ig G antibody titers and enhanced CD^(8+)T cells cytotoxic effect to kill tumor cells.These results indicated that GP-Al can be served as an efficient delivery system and adjuvant for the development of cancer vaccines especially small molecule antigens based cancer vaccines.

关 键 词：MUC 1 antigen GLYCOPEPTIDE GP-Al Adjuvant Antitumor vaccine 

分 类 号：TQ464[化学工程—制药化工]