合并叶酸降低的脑梗死患者症状和伴随疾病特征分析  

Symptoms and comorbidities in patients with cerebral infarction accompanied with folic acid reduction

作　　者：余爱勇 孙建军[2] 杨柳 赵迎春[1] 周克贵 陈晟[3] 赵玉武[4] YU Aiyong;SUN Jianjun;YANG Liu(Department of Neurology,Song Jiang Hospital Affiliated to Shanghai Jiao Tong University of Medicine,Preparatory Stage,Shanghai 201699,China)

机构地区：[1]上海交通大学医学院附属松江医院(筹)神经内科,上海201699 [2]上海市公共卫生临床中心感染与免疫科,上海201508 [3]上海交通大学医学院附属瑞金医院神经内科,上海200025 [4]上海交通大学附属第六人民医院神经内科,上海200233

出　　处：《中风与神经疾病杂志》2021年第8期681-684,共4页Journal of Apoplexy and Nervous Diseases

基　　金：松江区科学技术攻关项目(No.15SJGG30)。

摘　　要：目的研究脑梗死患者中,出现血清叶酸水平降低者的症状和伴随疾病特征。方法将叶酸<3.1 IU/ml者列为叶酸降低脑梗死组,共搜集372例患者;将叶酸≥3.1 IU/ml的患者,列为叶酸正常脑梗死组,共搜集到218例患者,比较两组患者的症状特征和伴随疾病特征。结果与叶酸正常组相比,叶酸降低组患者发生双下肢乏力、记忆力下降、走路不稳的比例高(P值分别=0.001、0.011、0.001)。通过二元非条件Logistic回归分析,症状性脑梗死史、痴呆、糖尿病、房性早搏、左心室肥大、高同型半胱氨酸都是发生叶酸降低独立相关因素(P值分别=0.000、0.011、0.002、0.002、0.032、0.006)。结论合并叶酸降低的脑梗死患者表现为双下肢乏力、走路不稳以及记忆力下降为主,多数合并有多次脑梗死病史、痴呆、高同型半胱氨酸血症和心脏损害,但合并糖尿病的比例较低。Objective To study the symptoms and comorbidities of patients with cerebral infarction combined with decreased serum folic acid levels.Methods Patients were classified as folic acid-reduced cerebral infarction group(n=372)and folate normal cerebral infarction group(n=218).The symptoms and concomitant disease state characteristics of the two groups were compared.Results Compared with the normal folic acid group,patients in the folic acid-reduced group developed bilateral lower extremity fatigue and decreased memory,walking instability(P=0.001、0.011、0.001,respectively).Through binary unconditional Logistic regression analysis,it was found that a history of symptomatic cerebral infarction,dementia,diabetes,atrial premature beat,left ventricular hypertrophy,homocysteine are all related to the reduction of folic acid(P=0.000、0.011、0.002、0.002、0.032、0.006 respectively).Conclusion Cerebral infarction patients with reduced folic acid manifested as bilateral lower extremity weakness,walking instability,and decreased memory.Most patients had multiple history of cerebral infarction,dementia,hyperhomocysteinemia,and heart damage.

关 键 词：叶酸 痴呆 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]