心因性非癫痫发作患者的临床特征及预后分析  

Analysis of clinical characteristics and prognosis of patients with psychogenic non-epileptic seizures

作　　者：周凤凰 刘凌[1] ZHOU Fenghuang;LIU Ling(Department of Neurology,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院神经内科,四川成都610041 [2]九江市第一人民医院神经内一科,江西九江332000

出　　处：《中风与神经疾病杂志》2021年第8期718-720,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨心因性非癫痫发作(PNES)的临床特征、预后及影响预后的相关因素。方法回顾性分析2011年1月-2019年12月于四川大学华西医院的152例行视频脑电图(VEEG)诊断为PNES患者,并分析影响预后的相关因素。结果患者主要症状为闭眼、身体僵硬、四肢抽搐、四肢颤抖和肢体非同相运动,42人(27.6%)脑电图异常,86人(67.7%)过去1 y未发作。发作持续时间>10 min(OR=2.715,P=0.045)、共病癫痫(OR=12.892,P=0.004)为影响预后的危险因素。结论PNES患者症状多样,脑电图异常很常见,约2/3患者1 y内无发作,发病持续时间长及共病癫痫是PNES预后的危险因素。Objective To investigate the clinical features,prognosis,and factors associated with the outcome of psychogenic non-epileptic seizures(PNES).Methods A retrospective analysis was performed on 152 patients diagnosed with PNES who underwent video electroencephalography(VEEG)in West China Hospital of Sichuan University from January 2011 to December 2019.The prognostic factors were analyzed.Results The main symptoms of the patients were eyes closure,body rigidity,limbs convulsions,limbs tremors and asynchronous limbs movements.Forty-two patients(27.6%)had abnormal EEGs.Eighty-six people(67.7%)were seizure-free in the past 12 months.The duration of seizure which is longer than 10 minutes(OR=2.715,P=0.045)and epilepsy comorbidity(OR=12.892,P=0.004)are the risk factors for prognosis.Conclusion Patients with PNES have various symptoms,and abnormal VEEG is very common.Approximately two thirds of patients were seizure-free in the past 12 months.Long duration of onset and epilepsy comorbidity are the risk factors for prognosis.

关 键 词：心因性非癫痫发作 症状 视频脑电图 预后 

分 类 号：R742.1[医药卫生—神经病学与精神病学]