一碳单位的代谢与结直肠癌关系的研究进展  

Research progress on the relationship between one carbon metabolism and colorectal cancer

作　　者：党学宁 陈潇健 崔龙[1] Dang Xuening;Chen Xiaojian;Cui Long(Department of Colorectal Surgery,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China)

机构地区：[1]上海交通大学医学院附属新华医院肛肠外科,上海200092

出　　处：《中华普外科手术学杂志（电子版）》2021年第4期468-472,共5页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：国家自然科学基金(81974060)。

摘　　要：一碳单位可用来进行核苷酸合成、底物甲基化和还原代谢,而包括丝氨酸代谢、甘氨酸代谢、甲硫氨酸循环以及叶酸循环在内的一碳单位的代谢则维持了细胞内的稳态及遗传稳定性,并在一定程度上支持了肿瘤的发生发展。结直肠癌是一种常见但发病机制尚不明确的恶性肿瘤,有着极高的发病率和死亡率。近来众多研究表明,一碳单位的代谢与结直肠癌关系密切,而且其代谢相关基因、代谢原料及代谢产物也已成为新的肿瘤诊断、预后标志物和治疗靶点。本文就一碳单位代谢与结直肠癌关系的研究进展进行综述,为后续研究提供参考依据。One carbon unit can be used for nucleotide synthesis,substrate methylation and reductionism,while one carbon metabolism,including serine metabolism,glycine metabolism,methionine cycle and folic acid cycle,maintains intracellular homeostasis and genetic stability,and to a certain extent support the tumorigenesis and development of cancer.Colorectal cancer(CRC)is a common but unclear malignant tumor with a high morbidity and mortality.Many recent studies have shown that the one carbon metabolism is closely related to colorectal cancer,and its metabolism-related genes,metabolic substrates and metabolites have also become new tumor diagnostic markers,prognostic markers and therapeutic targets.Therefore,this article reviews the research progress on the relationship between one-carbon metabolism and colorectal cancer,providing insight for the further research.

关 键 词：结直肠肿瘤 代谢 一碳单位 

分 类 号：R73[医药卫生—肿瘤]