cyclin D2和bcl-2在弥漫大B细胞淋巴瘤中的表达及其临床意义  

Expressions of cyclin D2 and bcl-2 in diffuse large B-cell lymphoma and their clinical significances

作　　者：马秋双[1] 李玲[2] 赵亚飞[3] 孙吉瑞 周炳娟[1] 耿慧娟 张金库[1] Ma Qiushuang;Li Ling;Zhao Yafei;Sun Jirui;Zhou Bingjuan;Geng Huijuan;Zhang Jinku(Department of Pathology,First Central Hospital of Baoding,Baoding 071000,China;Department of Dermatology,the First Central Hospital of Baoding,Baoding 071000,China;Department of Orthopedic,Baoding No.1 Hospital of TCM,Baoding 071000,China;Department of Laboratory,Baoding Infectious Diseases Hospital,Baoding 071000,China)

机构地区：[1]河北省保定市第一中心医院病理科,071000 [2]河北省保定市第一中心医院皮肤科,071000 [3]河北省保定市第一中医院骨科,071000 [4]河北省保定市传染病医院检验科,071000

出　　处：《白血病．淋巴瘤》2021年第7期407-410,共4页Journal of Leukemia & Lymphoma

基　　金：河北省保定市科技计划(1941ZF042)。

摘　　要：目的:探讨cyclin D2和bcl-2在弥漫大B细胞淋巴瘤(DLBCL)中的表达及其意义。方法:收集2015年1月至2020年3月在保定市第一中心医院手术切除的87例DLBCL组织及23例淋巴组织反应性增生(RLH)患者组织,采用免疫组织化学法检测DLBCL和RLH组织中cyclin D2和bcl-2蛋白的表达情况,分析二者表达间的相互关系及与DLBCL患者临床病理特征的关系。结果:DLBCL和RLH中cyclin D2蛋白阳性率分别为33.3%(29/87)、2.0%(1/23),bcl-2蛋白阳性率分别为60.9%(54/87)、7.0%(3/23);DLBCL中cyclin D2、bcl-2蛋白阳性率均高于RLH,差异均有统计学意义(χ^(2)=7.566, P=0.006;χ^(2)=17.512, P<0.01)。cyclin D2和bcl-2蛋白表达与DLBCL患者Ann Arbor分期、免疫分型有关(均 P<0.05),而与年龄、性别、肿瘤部位、组织类型均无关(均 P>0.05)。cyclin D2和bcl-2蛋白在DLBCL中的表达呈正相关( r=1.000, P<0.01)。 结论:cyclin D2和bcl-2可能与DLBCL的发生、发展相关,两者可能有一定的协同作用。Objective To investigate the expressions and significance of cyclin D2 and bcl-2 in diffuse large B-cell lymphoma(DLBCL)and their clinical significances.Methods The tissues of 87 DLBCL patients undergoing resection and 23 patients with lymphoid tissue reactive hyperplasia(RLH)in the First Central Hospital of Baoding from January 2015 to March 2020 were collected.Immunohistochemistry method was used to detect the expressions of cyclin D2 and bcl-2 in tissues of DLBCL and RLH,and the relationship between the expressions of cyclin D2 and bcl-2 as well as the association with the clinicopathological features of DLBCL patients.Results The positive rates of cyclin D2 protein in DLBCL and RLH were 33.3%(29/87)and 2.0%(1/23),the positive rates of bcl-2 protein in DLBCL and RLH were 60.9%(54/87)and 7.0%(3/23);the positive rates of cyclin D2 and bcl-2 in DLBCL were higher than those in RLH,and the differences were statistically significant(χ^(2)=7.566,P=0.006;χ^(2)=17.512,P<0.01).The expressions of cyclin D2 and bcl-2 proteins were related to the Ann Arbor staging and immunophenotype of DLBCL patients(all P<0.05),while not related to age,gender,cancer location,tissue type(all P>0.05).There was a positive correlation between the expressions of cyclin D2 and bcl-2 protein in DLBCL(r=1.000,P<0.01).Conclusions cyclin D2 and bcl-2 may be related to the development and progression of DLBCL,and both may have some synergies.

关 键 词：淋巴瘤 大B-细胞 弥漫性 细胞周期蛋白D2 基因 BCL-2 

分 类 号：R733.1[医药卫生—肿瘤]