颗粒粒径对中药二元混合粉体密度的影响  

Impact of Particle Size on Density of Binary Powder Mixture of Chinese Medicine

作　　者：唐正馨 李婉婷 曹君杰 李文静[1] 徐冰[1] 乔延江[1] TANG Zheng-xin;LI Wan-ting;CAO Jun-jie;LI Wen-jing;XU Bing;QIAO Yan-jiang(Department of Chinese Medicine Information Science,Beijing University of Chinese Medicine,Beijing Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine,Engineering Research Center of Key Technologies for Chinese Medicine Production and New Drug Development,Ministry of Education,Beijing 102400,China)

机构地区：[1]北京中医药大学中药信息学系,中药生产过程控制与质量评价北京市重点实验室,教育部中药制药与新药开发关键技术工程研究中心,北京102400

出　　处：《中国实验方剂学杂志》2021年第18期113-120,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82074033);中华中医药学会青年人才托举工程项目(2019-QNRC2-C11);北京中医药大学青年教师项目(2019-JYB-JS-015)。

摘　　要：目的:研究颗粒粒径对中药二元混合粉体密度的影响,为中药制剂处方设计提供参考。方法:构建3组具有不同粒径比(α)的中药二元混合体系,即木蝴蝶-微晶纤维素PH102(MCC PH102)(α=0.071 7),银柴胡-MCC PH200(α=0.158 7)和当归-MCC KG802(α=0.840 6)。每组按9个质量配比(90∶10,80∶20,70∶30,60∶40,50∶50,40∶60,30∶70,20∶80和10∶90)制备混合粉体,共得到27种含中药的二元混合粉体。对6种单一粉体和27种二元混合粉体的粒径分布、密度等参数进行表征。基于堆积理论和多变量分析阐释粒径相关参数对中药二元混合粉体的填充结构和密度的影响。结果:当归-MCC KG802二元混合体系的α大于替换置换率(αr=0.741 0),其密度与质量配比之间具有良好的线性关系,符合替换机制。木蝴蝶-MCC PH102二元混合体系的α小于临界比率(αc=0.154 0),其密度随组分质量比呈非线性变化,符合填隙机制。银柴胡-MCC PH200二元混合体系的α介于αc和αr之间,其密度受填隙机制和替换机制的双重影响。基于偏最小二乘法(PLS)模型的变量投影重要性(VIP)分析结果进一步证明混合质量配比(VIP值=1.62),α(VIP值=1.13)和D10(粒径分布累积至10%时对应的粒径,VIP值=1.06)是影响二元混合粉体密度的关键因素。结论:在中药二元混合粉体中,2种粉体的粒径差异越小,混合粉体密度和组分质量配比之间的关系越接近于线性。Objective:To investigate the influence of particle size on density of binary powder mixture of traditional Chinese medicine(TCM),and to provide reference for formulation design of TCM preparations.Method:Three groups of binary powder mixtures with different particle size ratio(α)were constructed,namely Oroxyli Semen-microcrystalline cellulose PH102(MCC PH102)(α=0.071 7),Stellariae Radix-MCCPH200(α=0.158 7)and Angelicae Sinensis Radix-MCC KG802(α=0.840 6).Binary powder mixtures with nine mass ratios(90∶10,80∶20,70∶30,60∶40,50∶50,40∶60,30∶70,20∶80 and 10∶90)were prepared for eachgroup,and 27 binary powder mixtures containing TCM were obtained.The particle size distribution,density and other parameters of six single materials and 27 binary powder mixtures were characterized.Based on the packing theory and multivariate analysis,the effects of particle size related parameters on the filling structure and density of the binary powder mixtures were elucidated.Result:Theαof Angelicae Sinensis Radix-MCC KG802 binary mixture system was larger than the replacement rate(αr=0.741 0),and its density had a good linear relationship with the mass ratio,which conformed to the replacement mechanism.Theαof Oroxyli Semen-MCC PH102binary mixture system was smaller than the critical ratio(αc=0.154 0),and its density was nonlinear with the mass ratio of components,which conformed to the filling mechanism.Theαof Stellariae Radix-MCC PH200binary mixture system was betweenαcandαr,its density was affected by both of replacement mechanism and filling mechanism.Based on the partial least squares(PLS)model,the variable importance in the projection(VIP)analysis further proved that the mixing mass ratio(VIP value=1.62),α(VIP value=1.13)and D10(the corresponding particle size when the particle size distribution accumulated to 10%,VIP value=1.06)were the key factors affecting the density of binary powder mixtures of TCM.Conclusion:In the binary powder mixtures of TCM,the linearity relationship between density and mass

关 键 词：粒径 二元混合粉体 密度 粒径比 堆积理论 填充结构 处方设计 

分 类 号：R22[医药卫生—中医基础理论] R943[医药卫生—中医学]