三种抑酸剂在胃溃疡治疗中的应用效果研究  

Study on the Application Effect of Three Kinds of Acid Suppressant in the Treatment of Gastric Ulcer

作　　者：崔雪靖[1] 王龙光[2] 张鹏飞[3] 穆晓燕[1] CUI Xuejing;WANG Longguang;ZHANG Pengfei;MU Xiaoyan(Department of Pharmacy,the Second Affiliated Hospital of Luohe Medical College,Luohe 462000,Henan,China;Luohe Medical College,Luohe 462000,Henan,China;Department of Gastroenterology,the Second Affiliated Hospital of Luohe Medical College,Luohe 462000,Henan,China)

机构地区：[1]漯河医学高等专科学校第二附属医院药学部,河南漯河462000 [2]漯河医学高等专科学校,河南漯河462002 [3]漯河医学高等专科学校第二附属医院消化内科,河南漯河462000

出　　处：《中国药物滥用防治杂志》2021年第4期609-612,共4页Chinese Journal of Drug Abuse Prevention and Treatment

基　　金：白求恩·医学科学研究基金(编号:TY171AN);漯河医学高等专科学校科研创新项目(编号:2019-LYZSKYB025)。

摘　　要：目的:探讨奥美拉唑钠、兰索拉唑与泮托拉唑治疗胃溃疡的有效性和安全性。方法:选择2019年6月至2020年12月漯河医学高等专科学校第二附属医院收治的93例胃溃疡患者,采用随机数字表法将其分成三组,每组各31例,奥美拉唑钠组(A组)、兰索拉唑组(B组)及泮托拉唑组(C组)。观察三组胃溃疡患者的治疗效果、不良反应发生率及复发率等。结果:A组的治疗总有效率(96.77%)显著高于B和C组;A组不良反应发生率(6.45%)和疾病复发率(3.23%)均显著低于B和C组;C组幽门螺旋杆菌(Hp)清除率(93.55%)显著高于A和B组,以上比较差异均有统计学意义(P<0.05)。结论:奥美拉唑治疗胃溃疡更安全有效、复发率低。泮托拉唑清除HP更有效。临床治疗中医生应结合患者病情及其他用药情况选择适合的抑酸药物,以提高临床疗效,降低不良反应。Objective: To study and analyze the clinical effects and safety of Omeprazole, Lansoprazole and Pantoprazole in the clinical treatment of patients with gastric ulcer. Methods: A total of 93 patients with gastric ulcer treated in the Second Affiliated Hospital of Luohe Medical College from June 2019 to December 2020 were randomly divided into three groups with 31 patients in each group: omeprazole sodium group(group A), lansoprazole group(group B) and pantoprazole group(group C) by random number table. The therapeutic effect, incidence of adverse reactions and recurrence rate of gastric ulcer were observed in three groups. Results: The total effective rate of A group was 96. 77%, which was significantly higher than that of B and C groups(P < 0.05);The rate of adverse reaction(6.45%) and the relapse rate(3.23%) in the A group which were significantly lower than that of B and C groups(P<0.05). The HP eradication rate of CGroup was 93.55%, which was significantly higher than that of B and C groups(P<0.05). Conclusion: Omeprazole is more effective, safer and lower recurrence rate in the treatment of gastric ulcer, Pantoprazole is highly efficacious for the removal of Hp. Therefore, doctors should make a reasonable choice of acid suppressants according to the patient’s condition and other medication, in order to improve the clinical effect and reduce the adverse reactions.

关 键 词：奥美拉唑钠 泮托拉唑 兰索拉唑 胃溃疡 不良反应 

分 类 号：R573.1[医药卫生—消化系统]