胸部放射治疗致肺癌患者急性放射性肺炎的影响因素分析  

Influencing Factors of Acute Radiation Pneumonia in Patients with Lung Cancer Caused by Thoracic Radiotherapy

作　　者：郭振江 郑力豪 么志军[1] 任振泰[1] 巴楠[1] GUO Zhenjiang;ZHENG Lihao;YAO Zhijun;REN Zhentai;BA Nan(Department of Radiotherapy,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;School of Basic Medical Science,Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第五附属医院放疗科,河南郑州450000 [2]郑州大学基础医学院,河南郑州450000

出　　处：《河南医学研究》2021年第23期4263-4265,共3页Henan Medical Research

基　　金：河南省高等学校重点科研项目计划(21A320046)。

摘　　要：目的分析胸部放射治疗致肺癌患者发生急性放射性肺炎的影响因素。方法选取2018年1月至2021年3月在郑州大学第五附属医院放疗科接受治疗的298例肺癌患者作为研究对象,回顾性分析患者相关临床资料,寻找急性放射性肺炎的影响因素。结果298例肺癌患者中,71例(23.83%)发生急性放射性肺炎。多因素logistic回归分析显示,有慢性肺部疾病史(OR=2.770,95%CI:1.154~6.653)、肿瘤直径≥5 cm(OR=1.966,95%CI:1.040~3.717)、放化疗同期(OR=2.010,95%CI:1.032~3.913)以及放疗总剂量≥60 Gy(OR=1.495,95%CI:1.044~2.140)为肺癌放疗后发生急性放射性肺炎的独立危险因素(P<0.05)。结论肺癌患者胸部放射治疗致急性放射性肺炎的发生率较高,其发生与慢性肺部疾病史、肿瘤直径、放化疗同期以及放射治疗总剂量独立相关,应根据患者自身病情和放射治疗情况,制定针对性预防与管理措施。Objective To analyze the influencing factors of acute radiation pneumonia in patients with lung cancer caused by thoracic radiotherapy.Methods A total of 298 patients with lung cancer who were treated in the Radiotherapy Department of the Fifth Affiliated Hospital of Zhengzhou University from January 2018 to March 2021 were selected as the research objects.The relevant clinical data of the patients were retrospectively analyzed to find the influencing factors of acute radiation pneumonia.Results Among 298 patients with lung cancer,71 cases(23.83%)developed acute radiation pneumonia.Multivariate logistic regression analysis showed that history of chronic lung disease(OR=2.770,95%CI:1.154-6.653),tumor diameter≥5 cm(OR=1.966,95%CI:1.040-3.717),concurrent radiotherapy and chemotherapy(OR=2.010,95%CI:1.032-3.913)and total radiation dose≥60 Gy(OR=1.495,95%CI:1.044-2.140)were independent risk factors for acute radiation pneumonia after radiotherapy for lung cancer(P<0.05).Conclusions The incidence of acute radiation pneumonitis caused by chest radiotherapy is high in patients with lung cancer.Its occurrence is independently related to the history of chronic lung disease,tumor diameter,concurrent radiotherapy and chemotherapy,and the total dose of radiotherapy.Doctors should formulate targeted prevention and management measures based on the patient’s own condition and radiation treatment.

关 键 词：肺癌 放射治疗 急性放射性肺炎 影响因素 

分 类 号：R734.2[医药卫生—肿瘤]