飞秒激光制备蛋白质智能软体执行器  

Femtosecond Laser Fabrication of Protein-Based Smart Soft Actuators

作　　者：胡昕宇 马卓晨 韩冰[2] 李春赫 张永来 Hu Xinyu;Ma Zhuochen;Han Bing;Li Chunhe;Zhang Yonglai(State Key Laboratory of Integrated Optoelectronics,College of Electronic Science and Engineering,Jilin University,Chayigcliun,Jilin 130012,China;State Key Laboratory of Precisioyi Testing Technology and Instrumeyits,Department of Precision Instruments,Tsinghua University,Beijing 100084,China)

机构地区：[1]吉林大学电子科学与工程学院,集成光电子学国家重点实验室,吉林长春130012 [2]清华大学精密仪器系,精密测试技术及仪器国家重点实验室,北京100084

出　　处：《中国激光》2021年第14期1-8,共8页Chinese Journal of Lasers

基　　金：国家重点研发计划(2017YFB1104600);国家自然科学基金(61935008,61775078,61905087,61590930);吉林省科技发展规划(20180101061JC)。

摘　　要：近年来,由柔软和自适应性强的材料组成的智能软体执行器以其高灵活性、生物兼容性和对高负载的机械弹性等一系列优势引起了人们的广泛关注。在各种制造技术中,飞秒激光双光子聚合技术已被证明是一种强有力的工具,促进了智能执行器支持的功能性微机械的发展。利用飞秒激光双光子聚合技术制备了一种基于蛋白质生物材料的对pH刺激响应的微机械,一步实现了蛋白质材料的三维构型和内部交联网络密度的三维分布,通过切换溶液的pH值实现了生物微机械"手臂"的捕捉和释放动作。这种制备策略在面向生物检测、细胞操控的器件研制方面具有广阔的应用前景。Objective In recent years, significant progress has been made in smart actuation devices;they have great potential for applications in microsurgery, cell manipulation, and biosensing. The majority of conventional actuators are mechatronic devices made of hard materials(e.g., metals, silicon, and silica) with low biocompatibility, softness, flexibility, and biodegradability, limiting their use in biomedical domains. Therefore, smart soft actuators made of soft and adaptive materials have significant advantages in this area. Biocompatible materials that can be directly applied to biomedical applications, such as cell manipulation and tissue sectioning, have significant advantages for future smart soft actuators. Thus, studying the treatment of biocompatible materials to create smart soft actuators critical for the development of intelligent micro-robots and micromechanical systems is crucial. In this paper, three-dimensional(3 D) micromechanical structures based on biocompatible BSA(bovine serum albumin) material are directly written using the femtosecond laser two-photon polymerization technique. The femtosecond laser’s high 3 D processing capabilities allow for 3 D direct writing of the micro-nano devices’ external contours while modulating the properties of the materials inside the structure. The relationship between the degree of micromechanical expansion under external environmental stimulation and the bending angle, as well as the size of the mesh density, is examined using the design technique presented in this research. Furthermore, a 3 D robotic arm model with capture and release capability is designed and fabricated. In the future, this design approach will has numerous applications in biomedical engineering, optical systems, micromechanical systems, and other domains.Methods In this study,BSA serves as the monomer,and MB(methylene blue)serves as the photoinitiator for the experiments.To make a viscous protein hydrogel,500 mg/mL BSA and 0.6 mg/mL MB were dissolved in ultrapure water(18.2 MΩ·cm,25 �

关 键 词：激光技术 飞秒激光 软体执行器 PH响应 蛋白质微纳结构 微机械 

分 类 号：TN249[电子电信—物理电子学]