From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?  

作　　者：Rita Caridade Silva Helena Sofia Domingues António J.Salgado Fábio G.Teixeira 

机构地区：[1]Life and Health Sciences Research Institute(ICVS),School of Medicine,University of Minho,Braga,Portugal [2]ICVS/3B’s Associate Lab,PT Government Associated Lab,Braga/Guimarães,Portugal

出　　处：《Neural Regeneration Research》2022年第5期933-936,共4页中国神经再生研究（英文版）

基　　金：the financial support from Prémios Santa Casa Neurociências Prize Mantero Belard for Neurodegenerative Diseases Research(MB-28-2019);supported by the European Regional Development Fund(FEDER);through the Competitiveness Internationalization Operational Programme(POCI);by National funds;through the Foundation for Science and Technology(FCT);under the scope of projects UIDB/50026/2020;UIDP/50026/2020 and POCI-01-0145-FEDER-029751;developed under the scope of the project NORTE-01-0145-FEDER-000023;supported by the Northern Portugal Regional Operational Programme(NORTE 2020);under the Portugal 2020 Partnership Agreement,through the European Regional Development Fund(FEDER);funded by ICVS Scientific Microscopy Platform,member of the national infrastructure PPBI-Portuguese Platform of Bioimaging(PPBI-POCI-01-0145-FEDER-022122)(to FGT)。

摘　　要：Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.Clinically,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons.Current treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal damage.Therefore,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease.For instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell death.Despite the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative process.Therefore,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based strategies.Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic neurons.Such approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease.Thus,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease.

关 键 词：disease-modifying strategies mesenchymal stem cells N-ACETYLCYSTEINE neuroprotection Parkinson's disease stem cells secretome 

分 类 号：R742.5[医药卫生—神经病学与精神病学]