Increased activation of the caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation:a case-control study  

作　　者：Pei-Ling Huang Song-Jian Wang Rui-Feng Sun Zi-Man Zhu Xiao-Ling Li Wen-Shan Li Meng-Yue Wang Meng Lin Wei-Jun Gong 

机构地区：[1]Department of Neurological Rehabilitation,Beijing Rehabilitation Hospital of Capital Medical University,Beijing,China [2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application,School of Biomedical Engineering,Capital Medical University,Beijing,China [3]Department of Neurological Rehabilitation,Beijing Rehabilitation Medicine Academy,Capital Medical University,Beijing,China

出　　处：《Neural Regeneration Research》2022年第5期1051-1058,共8页中国神经再生研究（英文版）

基　　金：supported by the Beijing Municipal Science and Technology Commission Capital Clinical Feature Applied Research Project of China,No.Z181100001718205(to WJG and PLH)。

摘　　要：Repetitive transcranial magnetic stimulation(r TMS)has been shown to effectively improve impaired swallowing in Parkinson's disease(PD)patients with dysphagia.However,little is known about how r TMS affects the corresponding brain regions in this patient group.In this casecontrol study,we examined data from 38 PD patients with dysphagia who received treatment at Beijing Rehabilitation Medicine Academy,Capital Medical University.The patients received high-frequency r TMS of the motor cortex once per day for 10 successive days.Changes in brain activation were compared via functional magnetic resonance imaging in PD patients with dysphagia and healthy controls.The results revealed that before treatment,PD patients with dysphagia showed greater activation in the precentral gyrus,supplementary motor area,and cerebellum compared with healthy controls,and this enhanced activation was weakened after treatment.Furthermore,before treatment,PD patients with dysphagia exhibited decreased activation in the parahippocampal gyrus,caudate nucleus,and left thalamus compared with healthy controls,and this activation increased after treatment.In addition,PD patients with dysphagia reported improved subjective swallowing sensations after r TMS.These findings suggest that swallowing function in PD patients with dysphagia improved after r TMS of the motor cortex.This may have been due to enhanced activation of the caudate nucleus and parahippocampal gyrus.The study protocol was approved by the Ethics Committee of Beijing Rehabilitation Hospital of Capital Medical University(approval No.2018 bkky017)on March 6,2018 and was registered with Chinese Clinical Trial Registry(registration No.Chi CTR 1800017207)on July 18,2018.

关 键 词：brain regions CAUDATE clinical trial DYSPHAGIA functional magnetic resonance imaging parahippocampal gyrus Parkinson's disease precentral gyrus repetitive transcranial magnetic stimulation saliva swallowing task 

分 类 号：R742.5[医药卫生—神经病学与精神病学]