T型钙通道在肿瘤中的研究进展  

Research progress of T-type calcium channel in cancer

作　　者：范刚 臧婧蕾 陈江 肖志宏 谢宇 Fan Gang;Zang Jinglei;Chen Jiang;Xiao Zhihong;Xie Yu(Department of Urology,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen 518060,China;School of Pharmacy,Changsha Health Vocational College,Changsha 410000,China;Department of Orthopaedics,the 2nd Affiliated Hospital of South China University,Hengyang 421001,China;Department of Urology,the Affiliated Cancer Hospital of Xiangya School of Medicine of Central South University,Hunan Cancer Hospital,Changsha 410006,China)

机构地区：[1]华中科技大学协和深圳医院泌尿外科,518060 [2]长沙卫生职业学院药学院,410000 [3]南华大学附属第二医院骨科,衡阳421001 [4]中南大学湘雅医学院附属肿瘤医院(湖南省肿瘤医院)泌尿外科,长沙410006

出　　处：《中国医师杂志》2021年第8期1266-1269,共4页Journal of Chinese Physician

基　　金：国家自然科学基金(82001489);广东省医学科研基金项目(A2021375);广东省基础与应用基础研究基金项目(2020A1515110158)。

摘　　要：在非兴奋型细胞中,电压门控性T型钙通道可通过激活、失活及缓慢灭活状态调控细胞内外钙离子浓度和膜电位。上述特性使得T型钙离子通道参与了多种肿瘤细胞的生物学特性的调控,包括细胞的增殖、分化、凋亡及侵袭、转移等。通过药物或基因方法抑制T型钙通道活性,可改变细胞相应通道电流和细胞内外离子分布,进而调控肿瘤细胞的生物学特性。本文对肿瘤进展过程中T型钙离子通道的电生理变化进行综述,以望为肿瘤发生发展的机制研究与治疗提供科学依据。In most non-excited cells,voltage-gated T-type calcium channels present three properties of activation,inactivation and slow inactivation,thus contribute to cellular calcium signaling and membrane potential.By which T-type calcium channels play an important role in many cancer cellular processes such as cell proliferation,differentiation,apoptosis,invasion,and metastasis.Inhibiting T-type calcium channels by drugs or genetic tools can change the related cellular currents and the intracellular Ca2+,thereby regulating the biological tumorigenesis.This article reviews the electrophysiological of T-type calcium channels during tumor progression,aims to provide a scientific basis for the study and treatment in cancer.

关 键 词：钙通道 T型 肿瘤 细胞增殖 细胞凋亡 

分 类 号：R730.2[医药卫生—肿瘤]