儿童原发性免疫缺陷病与炎症性肠病  

Primary immunodeficiency disease and inflammatory bowel disease in children

作　　者：林毅[1] 张秋业[1] LIN Yi;ZHANG Qiu-ye(Pediatric Health Center,Department of Pediatric Cardiology,Nephrolo­gy and Rheumatism,Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院儿童医学中心儿童肾脏风湿免疫科,山东青岛266003

出　　处：《中国实用儿科杂志》2021年第7期485-490,共6页Chinese Journal of Practical Pediatrics

摘　　要：炎症性肠病(IBD)在儿童相对少见,其发生率在原发性免疫缺陷病(PID)患者显著增高。IBD易发生于PID中的免疫失调性疾病、吞噬细胞缺陷、自身炎症性疾病,在联合免疫缺陷病、伴典型表现的联合免疫缺陷综合征中也有报道。PID伴IBD患者发病年龄早,临床表现重,内镜下表现不典型,对传统治疗方案反应差。文章仅就PID合并IBD的机制、临床表现及治疗进行综述。The morbility of inflammatory bowel disease(IBD)is low in normal children,but is relatively high in some kinds of primary immunodeficiency diseases(PID).Some kinds of PID are easy to combine with IBD,for example,diseases of immune dysregulation,congenital defects of phagocytes,autoinflammatory disease,combined immunodeficiencies,and combined immunodeficiency syndrome with typical features.PID combined with IBD has different clinical features,for example,the small onset age,severe clinical manifestations,atypical manifestations in endoscopy,and resistance to traditional treatment.In this article we reviewed the mechanisms as well as the clinical features and treatment of PID combined with IBD.

关 键 词：原发性免疫缺陷 炎症性肠病 克罗恩病 溃疡性结肠炎 儿童 

分 类 号：R72[医药卫生—儿科]