消溃清幽汤联合四联疗法治疗幽门螺杆菌阳性消化性溃疡临床研究  

Clinical Study on Xiaokui Qingyou Tang Combined with Quadruple Chemotherapy for Hp Positive Peptic Ulcer

作　　者：王环芬 应尚艳 WANG Huanfen;YING Shangyan(Outpatient department of Wenzhou Hospital of traditional Chinese medicine,Wenzhou,Zhejiang 325000)

机构地区：[1]温州市中医院门诊部,浙江温州325000

出　　处：《新中医》2021年第16期88-92,共5页New Chinese Medicine

摘　　要：目的:观察消溃清幽汤联合四联疗法治疗幽门螺杆菌(Hp)阳性消化性溃疡的临床疗效。方法:选取120例Hp阳性消化性溃疡患者,按随机数字表法分为对照组和治疗组各60例。对照组给予四联疗法(奥美拉唑+阿莫西林+克拉霉素+果胶铋)治疗,治疗组在对照组的基础上给予消溃清幽汤治疗。治疗8周后,评估2组临床疗效和Hp根除率;对2组治疗前后的中医证候积分、胃黏膜屏障防御功能进行评价;并观察记录治疗期间的不良反应情况。结果:治疗组总有效率为86.67%,对照组为68.33%,2组比较,差异有统计学意义(P<0.05)。治疗组Hp根除率为75.00%,对照组为53.33%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05);治疗后,2组中医证候积分均较治疗前降低(P<0.05),且治疗组中医证候积分低于对照组(P<0.05)。治疗前,2组血清β-连环蛋白(β-catenin)、骨桥蛋白(OPN)水平比较,差异无统计学意义(P>0.05);治疗后,2组血清β-catenin、OPN水平均较治疗前降低(P<0.05);且治疗组2项指标均低于对照组(P<0.05)。治疗组不良反应发生率为11.67%,对照组为13.33%,2组比较,差异无统计学意义(P>0.05)。结论:针对HP阳性消化性溃疡患者给予消溃清幽汤联合四联疗法治疗安全有效,能改善患者临床症状,提高疗效及Hp根除率,有效调节β-catenin、OPN水平,进而保护受损的胃肠道黏膜。Objective:To observe the clinical effect of Xiaokui Qingyou tang combined with quadruple chemotherapy for helicobacter pylori(Hp) positive peptic ulcer. Methods: A total of 120 cases of patients with HP positive peptic ulcer were selected and divided into the control group and the treatment group according to the random number table method,60 cases in each group. The control group was given quadruple chemotherapy with omeprazole, amoxicillin, clarithromycin and bismuth pectin,and the treatment group was additionally treated with Xiaokui Qingyou tang based on the treatment of the control group. After eight weeks of treatment,the clinical effect and Hp eradication rate in the two groups were evaluated.Before and after treatment, Chinese medicine syndrome scores and gastric mucosal barrier defense function in the two groups were evaluated. During treatment,the adverse reactions were observed and recorded. Results:The total effective rate was 86.67% in the treatment group and 68.33% in the control group,the difference being significant(P<0.05). The Hp eradication rate was 75.00% in the treatment group and 53.33% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of Chinese medicine syndrome scores between the two groups(P>0.05). After treatment, Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the score in the treatment group was lower than that in the control group(P<0.05). Before treatment, there was no significant difference being found in the comparison of the levels of β-catenin and osteopontin(OPN) in serum between the two groups(P>0.05). After treatment,the levels of serum indexes of β-catenin and OPN in the two groups were decreased when compared with those before treatment(P<0.05),and the above two indexes in the treatment group were lower than those in the control group(P<0.05). The incidence of adverse reactions was 11.67% in the treatment g

关 键 词：消化性溃疡 幽门螺杆菌 消溃清幽汤 四联疗法 Β-连环蛋白 骨桥蛋白 

分 类 号：R573.1[医药卫生—消化系统]