主动脉瘤相关通路基因多态性研究进展  

Research progress of gene polymorphisms related to aortic aneurysm

作　　者：杨超[1] 李潭[2] 张旭[3] YANG Chao;LI Tan;ZHANG Xu(Trauma Center and Department of Burns,the First Hospital of China Medical University,Shenyang 110001,China;Department of Cardiovascular Ultrasound,the First Hospital of China Medical University,Shenyang 110001,China;Department of medical administration,Department of Surgery,the First Hospital of China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院创伤中心/烧伤科,辽宁沈阳110001 [2]中国医科大学附属第一医院心血管超声科,辽宁沈阳110001 [3]中国医科大学附属第一医院医务部/手术部,辽宁沈阳110001

出　　处：《解剖科学进展》2021年第4期504-507,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金青年基金项目(82001828)。

摘　　要：主动脉瘤是主动脉壁结构损害导致的主动脉局部或弥漫性的异常扩张、撕裂或破裂。免疫炎症反应是参与主动脉瘤形成的重要机制,参与免疫炎症通路激活的基因及其多态性可能在主动脉瘤发生、发展中起着关键的作用。本文就主动脉瘤相关通路的基因多态性研究进展做一综述,为进一步理解主动脉瘤的病理生理学基础、寻找有效的治疗方案提供依据。An aortic aneurysm is a local or diffuse abnormal dilation, tear or rupture of the aorta caused by structural damage of the aortic wall. Immune inflammatory response is an important mechanism involved in the formation of aortic aneurysm. Genes and their polymorphisms involved in the activation of immune inflammatory pathway may play a key role in the occurrence and development of aortic aneurysm. Therefore, this paper reviews the research progress of gene polymorphism of aortic aneurysm-related pathway, in order to further understand the pathophysiological basis of aortic aneurysm and find effective treatment.

关 键 词：主动脉瘤 病理生理学基础 主动脉壁 结构损害 免疫炎症反应 基因多态性 炎症通路 弥漫性 

分 类 号：R732.2[医药卫生—肿瘤]