半胱氨酸蛋白酶抑制SN在肝细胞癌中的表达意义  

The significance of cystatin SN expression in hepatocellular carcinoma

作　　者：吴杰[1] 高飞[1] 张雪松[1] 王魁阳 隋成旭 张亮[1] 姚远方 宋磊[1] Wu Jie;Gao Fei;Zhang Xuesong;Wang Kuiyang;Sui Chengxu;Zhang Liang;Yao Yuanfang;Song Lei(Department of Interventional Therapy,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,Liaoning,China)

机构地区：[1]大连医科大学附属第二医院综合介入科,辽宁大连116027

出　　处：《肝癌电子杂志》2021年第2期33-38,共6页Electronic Journal of Liver Tumor

基　　金：大连市医学科学研究计划项目(1712033)。

摘　　要：目的:分析肝细胞癌(hepatocellular carcinoma,HCC)中半胱氨酸蛋白酶抑制SN的表达水平及其与各临床病理特征之间的关系,探讨半胱氨酸蛋白酶抑制SN表达水平与HCC患者预后之间的联系。方法:收集72例原发性肝癌患者的临床信息,采用免疫组织化学法检测72份HCC组织及60份癌旁组织蜡块标本中半胱氨酸蛋白酶抑制SN的表达,分析半胱氨酸蛋白酶抑制SN在72份HCC组织与60份癌旁组织中的表达情况,及其相关临床意义。结果:半胱氨酸蛋白酶抑制SN在60份癌旁组织中均呈现强阳性表达(+++),其表达强度均明显强于HCC组织,两组表达程度有显著性差异(P<0.05)。HCC组织中半胱氨酸蛋白酶抑制SN表达水平高的患者生存预后均优于其表达水平低的患者(均P<0.05)。结论:HCC组织半胱氨酸蛋白酶抑制SN的表达相比癌旁组织明显较低,且半胱氨酸蛋白酶抑制SN高表达的HCC患者生存预后均要明显优于其低表达的患者。Objective:To analyze the expression level of cystatin Sn in HCC and its relationship with clinicopathological features,and to explore the relationship between the expression level of cystatin SN and the prognosis of HCC patients.Methods:The clinical data of 72 patients with primary liver cancer were collected,and the expression of cystatin SN was detected by immunohistochemistry in 72 HCC and 60 paraffin samples of paracancerous tissues.Results:The expression intensity of cystatin SN was significantly higher than that of HCC(P<0.05).The patients with high expression level of cystatin SN in HCC were better than those with low expression level in disease-free survival and overall survival(P<0.05).Conclusion:The expression of cystatin SN in HCC is significantly lower than that in paracancerous tissues,and the HCC patients with high expression of cystatin SN were significantly better than those with low expression in disease-free survival and overall survival.

关 键 词：肝细胞癌 半胱氨酸蛋白酶抑制SN 无瘤生存 总生存 

分 类 号：R735.7[医药卫生—肿瘤]